Basic & Clinical Medicine ›› 2010, Vol. 30 ›› Issue (8): 857-861.
• 研究论文 • Previous Articles Next Articles
Zhi-en ZHOU, Han-zhong LI, Wei-gang YAN
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Abstract: Objective To study the clinical value of AR expression and its gene gain/lose in evaluating the prognosis of prostate cancer. Methods 19 patients were aged 58~90 years, and their PSA level before therapy were (13.3~120)ng/mL. As for gleason score, two had high differentiation (gleason score<7) and 17 had low differentiation (gleason score>=7).Using immunohistochemical and FISH method, we analyzed the expression of AR and its gene gain/lose in PC tissues from 19 samples. The correlation of AR expression and AR gene gain/lose with tumor prognosis in prostate cancer were analyzed in combination with the clinical data. Results 2 of 19 were found AR gene gain, the positive rate was 10.5%. The two positive samples were both from the survival group. However, none of the 6 samples from the death group was found AR gene gain. AR positive intensity of the unrecurent group were significantly higher than the death group(P<0.05). Conclusions Strong positive degree of AR expression in immunohistochemical test and AR gene gain occurring before therapy may be indicators for favorable prognosis in prostate cancer.
Key words: Prostate cancer, Prognosis, AR, Gene gain/lose
Zhi-en ZHOU; Han-zhong LI; Wei-gang YAN. The correlation of AR expression and AR gene gain/lose with tumor prognosis in prostate cancer[J]. Basic & Clinical Medicine, 2010, 30(8): 857-861.
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