Abstract: The family of Kazal-type serine protease inhibitor (SPINK) correlates with chronic pancreatitis, Netherton syndrome, esophageal carcinoma, and other humane diseases. The functions of SPINK1, SPINK5 and SPINK7 have been identified. However, other members remain to be explored. In this review, we summarized locations of SPINK genes, protein structures, functions of SPINK proteins, and the relationship between SPINK family and humane diseases.

Key words: SPINK, Chronic Panceatitis, Netherton Syndrome, Esophageal Carcinoma