Basic & Clinical Medicine ›› 2010, Vol. 30 ›› Issue (4): 383-388.

• 研究论文 • Previous Articles     Next Articles

Atorvastatin Alleviating Vascular Remodeling of Renal Hypertensive Rat

Yong-hong CHEN, Song YANG, Jian-zhong ZHOU   

  1. the First Affiliated Hospital of Chongqing Medical University
  • Received:2009-06-12 Revised:2009-09-27 Online:2010-04-05 Published:2010-04-05
  • Contact: Jian-zhong ZHOU

Abstract: Objective To investigate the roles of endothelial lipase(EL) in renal hypertensive vascular remodeling and the effects of atorvastatin intervention. Methods Renal hypertension rat models were constructed through two-kidney-one-clip technique. Twenty-one rats were randomly divided equally into sham operation group (Sham),renal hypertension group(RH),atorvastatin-treated group(ATV).Atorvastatin treatment(30 mg/kg·d) was started four weeks after model construction and lasted 8 consecutive weeks, given through lavage. All rats were evaluated caudal systolic blood pressure(SBP),microscopic changes in vascular structure and ratio of intima media thickness to lumen diameter(MT/LD) of thoracic aorta. The expressions of EL and nuclear transcription factor-κB (NF-κB)were assessed with immunohistochemical staining, the expression of EL mRNA with Real-time quantitative RT-PCR. Results Compared with Sham group,RH group showed significant increase in SBP、MT/LD and the expressions of EL、EL mRNA and NF-κB, and significant decrease in HDL、TC and LDL levels(P<0.05).As compared with RH group, MT/LD and the expressions of EL、EL mRNA and NF-κB of ATV group were significantly decreased, HDL level significantly increased, TC and LDL levels significantly decreased(P<0.05). Conclusions Atorvastatin was shown to alleviate the development of vascular remodeling in renal hypertensive rats, possibly associated with decreased expression of EL.

Key words: Endothelial lipase, Vascular remodeling, Atorvastatin