Abstract: Objective:To investigate the relationship between the AT2-receptor 1675A/G gene polymorphism and essential hypertension in men. Methods: The studied objects were born in Jining city 113 EH male patients are EH group , with 101 healthy people as control group.To gather clinical data and extract DNA from blood with reagent-case.The 1675A/G polymorphism of AGTR2 gene was detected by PCR , HRM and gene sequencing. Result: There were difference in genetypes(AA、GG) distribution and allele frenqency of AGTR2 1675A/G between male EH and control group(p＜0.05). Genotypes（AA、GG） distribution in EH group: 56（49.6％）,57（50.4％），is significantly higher than in control group, 32 (31.7%), 69 (68.3%), (p < 0.05). Allele frenqency in EH group: A:112（49.6%）and G:114（50.4%）, is significantly higher than in control group: 32（31.7％）and 69（68.3％）（p＜0.05）. Conclusion:The 1675A/G polymorphism of AGTR2 gene may be associated with male EH in Jining area ，Shandong province.

Key words: Essential Hypertension (EP), male, AngiontensinⅡtype2-receptor(AT2R), Genetic Polymorplism, genetype