Basic & Clinical Medicine ›› 2010, Vol. 30 ›› Issue (12): 1288-1292.

• 研究论文 • Previous Articles     Next Articles

Adiponectin gene SNP-11377 and SNP-4522 haplotypes are associated with metabolic syndrome

LI Yi-ping 1,YANG Man 1,XIONG Yu-xin 1,LI Xian-li 1,XU Bo 1,YAO Yu-feng 2,ZHANG Ying 1   

  1. 1. The Second People Hospital of Yunnan Province2. Institute of Medical Biology, CAMS & PUMC
  • Received:2010-03-10 Revised:2010-04-28 Online:2010-12-05 Published:2010-12-05
  • Contact: ZHANG Ying

Abstract: Objective To investigate whether the adiponectin gene single nucleotide polymorphisms (SNP) are associated with the metabolic syndrome. Methods Using polymerase chain reaction-based restriction fragment-lenngth polymorphism (PCR-RFLP) genotyped SNP-11391、SNP-11377、SNP-4522、SNP+45 and SNP+331 of adiponectin gene, and estimated the association of the five SNPs with metabolic syndrome(MS). Results ⑴Adiponectin gene SNP-11391 and SNP+331 are not polymorphisms in Han population of Kunming City. ⑵In MS group, SNP-11377G-SNP-4522T haplotype frequency is lower than control group (P﹤0.05), SNP-11377C-SNP-4522T and SNP-11377G-SNP-4522C haplotype frequencies are higher than control group (P﹤0.05 and P﹤0.01) ; Conclusions In Han population of Kunming City, SNP-11377G-SNP-4522T haplotype maybe associated with lower risk of MS, and SNP-11377C-SNP-4522T and SNP-11377G-SNP-4522C haplotypes maybe associated with higher risk of MS.

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