Basic & Clinical Medicine ›› 2009, Vol. 29 ›› Issue (9): 920-923.

• 研究论文 • Previous Articles     Next Articles

Association analysis of XRCC1-Arg399Gln polymorphism with thyroid-associated ophthalmopathy

Wen-hao MA, Rui QIN, DShao-kang TENG   

  1. Dept,of Ophthalmology of Affiliated Hosipital,Youjiang Medical College for Nationalities Dept.of Anatomy, Youjiang Medical College for Nationalities
  • Received:2008-11-24 Revised:2008-12-17 Online:2009-09-20 Published:2009-09-20
  • Contact: Wen-hao MA,

Abstract: Objective To investigate the association of XRCC1-Arg399Gln polymorphism with hyroid-tassociated ophthalmopathy (TAO ) . Methods XRCC1-Arg399Gln polymorphism was determined by PCR-RFLP in 182 patients with TAO and 182 healthy subjects. Results The significant difference of the allelic frequency distribution was found between TAO and control group(P〈0.001),The frequency of A allelic in TAO was higher than that in control group .Compared with subjects carrying GG allele, the risk of TAO for the individuals carrying GA+AA allele increased(OR 1.863,95%CI 1.228~2.826,P<0.05). The OR of TAO for individuals carrying A allele or cigarette smokers was respectively 1.343(95%CI 0.764~2.36) and 2.0274(95%CI 1.121~3.667).But The combination of the above two made the OR of TAO up to 4.981(95%CI 2.697~9.1998). Conclusion Allele A in XRCC1Arg399G1n may be associated with TAO. Potential interactions were found among XRCC1-Arg399G1n polymorphisms and cigarette smoking.

Key words: thyroid-associated ophthalmopathy (TAO ), XRCC1, genetic polymorphism

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