Basic & Clinical Medicine ›› 2009, Vol. 29 ›› Issue (8): 872-874.

• 临床园地 • Previous Articles     Next Articles

DMD gene defection analysis of 135 patients of duchenne muscular dystrophy

Yang YAN, Xiao-feng YANG, Fu-hua YIN, Sheng-nan HUANG   

  1. the Four Six Three Hospital of Liberation Army
  • Received:2008-06-30 Revised:2008-08-28 Online:2009-08-20 Published:2009-08-20
  • Contact: Yang YAN,

Abstract: objective:deletion detection of Duchenne muscular dystrophy(DMD);method: the 135 patients use polymerase reaction of amplification with 12 dystrophin exons, polyacrylamide gel electrophoresis make gene analysis; result:The deletion of different region was found in 54 patients; conclusion: the deletion region is concentrated in 45-53exons,the deletion of 48 exons is maxium.

Key words: DMD, gene diagnosis, PCR