Basic & Clinical Medicine ›› 2009, Vol. 29 ›› Issue (8): 867-871.
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Mei LI, Xiao-ping XING, Wei-bo XIA, Ying-ying HU, Ou WANG, Yan JIANG, Huai-cheng LIU, Xun-wu MENG
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Abstract: Objective To assess the efficacy and tolerance of infusions of ibandronate on Beijing postmenopausal osteoporotic women. Methods A randomized study among 60 postmenopausal women receiving either 2-hour infusions of ibandronate(2mg) in every three months or oral 70mg/week alendronate during one year. The bone mineral density (BMD, by DXA), serum carboxy-telopeptide cross-links of type I collagen(CTX, by chemiluminescence) and alkaline phosphatase (ALP,by autonomic analysor) were measured to evaluate the efficacy. The side effects, liver and kidney function were observed to assess the tolerability. Results: 59 patients completed the observation. After one year of treatment, at the sites of lumbar spine, femoral neck and trochanter, ibandronate increased the BMD by 6.3%, 2.5% and 0.1% (lumbar P <0.001,femoral neck P <0.01), and alendronate changed the BMD by 3.7%, 4.9%, -0.5% respectively(lumbar and femoral neck, P <0.001). There were no significant differences of BMD between two groups after treatment. In ibandronate and alendronate group, ALP levels were decreased by 15.8% and 17.2%,CTX levels decline by 78.1% and 43.2%( P <0.001). The liver and kidney function were in normal range. Mild muscle pain and fever in the first month after infusion (26.7%) was the main side effects of ibandronate. Mild upper GI effect(13.3%) was the common effect of alendronate. Conclusions Intermittent infusions of ibandronate significantly increased BMD and inhibited bone resorption with good tolerance in postmenopausal osteoporotic women.
Key words: Osteoporosis, ibandronate, alendronate
Mei LI; Xiao-ping XING; Wei-bo XIA; Ying-ying HU; Ou WANG; Yan JIANG; Huai-cheng LIU; Xun-wu MENG. Intermittent infusions of ibandronate for treatment of Beijing postmenopausal osteoporotic women[J]. Basic & Clinical Medicine, 2009, 29(8): 867-871.
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