Abstract: Objectives: We aimed to explore the genetic susceptibility of three polymorphisms within GNB3、ADD1 and ADRB2 genes to high altitude pulmonary edema (HAPE). Methods: The rs5443 in GNB3 gene, rs4961 in ADD1 gene and rs1042713 in ADRB2 gene were genotyped by polymerase chain reaction-restriction fragment length polymorphism, as well as allelic specific polymerase chain reaction. Results: No significant frequency differences were found in terms of any of the three polymorphisms between the HAPE and control groups. Meanwhile, no relationships were observed between the haplotypes of the three polymorphisms and HAPE. Conclusion: All of the studied polymorphisms within GNB3、ADD1、ADRB2 genes might not be involved in the pathogenesis of HAPE.

Key words: GNB3, ADD1, ADRB2, HAPE, polymorphism, haplotype