Abstract: Objective To investigate the clinical and pathological characteristics as well as immunophenotypes of subcutaneous panniculitis-like T-cell lymphoma to explore its differential diagnosise with other similar diseases. Methods The clinical、histological and immunophenotypic features of 6 cases were described in detail and related literatures were reviewed. Results All of 6 patients presented with subcutaneous nodules or /and erythematous plaques without lymph nodes swelling and with fever but one case , one developed to ulcer from its nodules. All of 6 patient presented typical histological changes and 2 of them associated with prominent hemophagocytic syndrome. The neoplastic cells were of T-cell phenotype. Two patients followed an aggressive clinical course with short survival of 9-16 months and four patients who treated with chemotherapy have an improved survival, but two of them had been recurred. Conclusions　SPTCL is a rare type of T-cell lymphoma which has a clinical and pathological characteristics relatively, and it should be differentiated from benign panniculitis or other lymphomas of the skin.

Key words: Skin lymphoma, T-cell, Panniculitis