Abstract: Objective To compare the differences of cardiac function and interstitial remodeling between DHF and SHF rabbit models. Methods To establish DHF model with abdomial aorta ligation and SHF model with abdomial aorta ligation plus catheterization abdomial aorta ligation and catheterization. The cardiac function was detected by UCG parameters and homodynamic parameters. The collagen content was detected through hydroxyproline colorimetric assay and collagen area(CA), collagen volume fraction(CVF) and area ratio ofⅠto Ⅲ type collagen with PSR. Result Compared with control group, there were significantly increasing thickness and stiffness of myocardium, impaired diastolic function but normal ejection fraction (EF), and significantly increasing collagen content, CA, CVF and area ratio ofⅠto Ⅲ type collagen in DHF group; there were significantly enlarging heart chamber, decreasing systolic function, and significantly increasing collagen content, CA, CVF but decreasing ratio ofⅠto Ⅲ type collagen in SHF group (P<0.05 or P<0.01). Conclusion DHF and SHF rabbit models were established successfully, which can represent different clinical types and provide technical support to future research..

Key words: diastolic heart failure, systolic heart failure, cardiac function, collagen