Abstract: Objective To anaylaze the correlation between cold hemoagglutinin(CHA) and diffuse panbronchiolitis(DPB) in Chinese patients. Methods 18 patients diagnosed as DPB from December 1996 to July 2008 in Peking Union Medical College and 60 cases of DPB reported in mainland China from 1996 to 2008 were enrolled in the study. Result Of 18 patients diagnosed DPB in Peking Union Medical College, Only 1 patient had titer of CHA≥1:64. Of 60 cases in mainland China, 48 cases had CHA result. CHA was positive in 54.1% all cases.There may be some correlation between positive-Frequency of CHA and treatment、population et al. Conclusions Low positive-frequency of CHA in Chinese subjects, which is different from Japanese DPB patients, suggests that CHA may not be applicable to the clinical diagnostic criteria for Chinese patients.

Key words: Diffuse panbronchiolitis, Cold hemoagglutinin