Abstract: Objective To investigate the interference role that adipokines----adiponectin and leptin exert to hepatocellular apoptosis in mice suffering acute liver injury induced by Concanavalin A (ConA). Methods In the present study, 26 male BALB/c mice were divided to four groups randomly: ConA group( 8 mice): ConA were intravenous (i.v.) injected; adiponectin group(5 mice): adiponectin were intraperitoneal (i.p.) injected before ConA i.v. injected; leptin group(5 mice): leptin were i.p. injected before ConA i.v. injected; control group(8 mice): normal saline was i.v. injected. Mice were sacrificed 8 hours after ConA-treatment for observing hepatic pathology and hepatocellular apoptotic rate. Results Comparison to ConA group ,the mice in adiponectin group developed reduced hepatic injury and lower ALT level and hepatocellular apoptotic rate（p<0.01）, but those in leptin group developed heightened hepatocellular apoptotic rate（p<0.01）and similar ALT levels. Conclusions Adiponectin might inhibit hepatocellular apoptosis and control hepatic inflammation, but leptin improved hepatocellular apoptosis and had no effection on ALT levels induced by ConA .