Basic & Clinical Medicine ›› 2008, Vol. 28 ›› Issue (8): 835-840.
• 研究论文 • Previous Articles Next Articles
Chuan-min WANG, Chun-hua QIE, Bo QIN
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Abstract: Objective To explore the treatment effects and mechanisms of Hyper-IL-6 mediated by recombinant adenovirus on rat with acute liver failure(ALF).Methods The eighty ALF rats were randomly divided into 4 groups, normal saline was injected for non-infection group ;Ad0,AdIL-6 and AdHIL-6 was respectively injected for group Ad0,group AdIL-6,group AdHIL-6.Subsequently to determine the index of hepatic function,the liver pathology,the hepatocelluar apoptosis in situ,the expression of PCNA and caspase-3 in liver tissue,and to observe the survival rate of rats for 14 days.Results The contents of serum ALT and TB,and apoptotic index in rats of group AdHIL-6 were markedly decreased than that of the other groups,inversely the significant expression of PCNA(P<0.01).The liver pathological change was mild,and owned higher survival rate at the end of 14 days in group AdHIL-6;Conclusion It was significant that the potency of Hyper-IL-6 enhancing hepatocelluar proliferation and defending hepatocyte apoptosis on the rats with ALF. It can effectively ameliorate liver function and histology,and improve the survival of rats with ALF.
Chuan-min WANG; Chun-hua QIE; Bo QIN. Effect of recombinant adenovirus vector containing Hyper-IL-6 on acute liver failure rats[J]. Basic & Clinical Medicine, 2008, 28(8): 835-840.
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