Abstract: Objective The aim of this study was to explore the effects of SLC concentration gradient on suppression of tumor immune escape. Methods According to different SLC concentration, there were six groups. The HLA-Ⅰexpression and apoptosis of MCF-7 were detected with FCM ,and intracellular Bcl-2 expression was analyzed by western blot. The productions of TGF-βwere detected with ELISA. Results In a certain range of concentration gradient, following SLC increase, HLA-Ⅰexpression level on MCF-7 was improved, and the apoptosis was induced but Bcl-2 expression was enhanced ,moreover, the secretion of TGF-β was suppressed. Conclusion SLC inhibited tumor immune escape.