Abstract: Objective:study the clinical function of Tiopronin with comprehensive chemotherapy in the treatment of advanced gastric cancer.Method:70 advanced gastric cancer patients who lost surgical operation treatment opportunity were enrolled into this study.　70 patients with advanced gast ric cancer were divided into two groups randomly(treatment group 35 patients and control group 35 patients).Single apply FolFox in control group;treatment group adopt the FolFox chemotherapy project and Tiopronin 0.3 iv qd d1-d5.Evaluate the curative effects and adverse reactions.Results:9 patients achieved complete response (CR) , 8 patients partial response ( PR) , 15 patients no change ( NC) , 3 patients progression disease ( PD) 2 patients adverse reactions in treatment group and 8 patients achieved complete response (CR) , 6 patients partial response ( PR) , 17 patients no change ( NC) , 4 patients progression disease ( PD) 8 patients adverse reactions in control group.Conclusion: Tiopronin with comprehensive chemotherapy in the treatment of advanced gastric cancer,It can improve efficacy and the quality of life and reduce the adverse reactions of chemotherapy.