Abstract: Objective To observe the effects of electrical stimulation of paraventricular nucleus (PVN) on gastric mucosal cellular apoptosis，proliferation，and expression of BCL-2，BAX induced by gastric ischemia-reperfusion (GI-R), investigate the cellular mechanisms of protection of PVN on GI-R injury . Methods After electrical stimulation of PVN, the experimental model of GI-R were established by clamping the celiac artery for 30 min and then reperfusing the artery for 30 min，1 h，3 h，or 6 h respectively. We used immunohistochemistry to detect the gastric mucosal cells apoptosis, proliferation and the expression of BCL-2,BAX. Results Compared with GI-R group，the electrical stimulation of PVN markedly decreased gastric mucosal cellular apoptosis，increased the proliferation，and promoted the protein expression of BCL-2，but markedly inhibited the protein expression of BAX at 30 min,1 h, 3 h after reperfusion respectively. Conclusion The protective effect of PVN on GI-R injury is associated with up-regulation of expression of BCL-2 and down-regulation expression of BAX，and then inhibiting gastric mucosal cellular apoptosis and promoting proliferation induced by GI-R injury.