Abstract: To study the effect of selective cyclooxygenase-2 (COX-2) inhibitor Parecoxib (Par) on progression of renal lesion and fibrosis in rats after unilateral ureteral obstruction (UUO). Methods: Experimental rats were divided into three groups: UUO group, Par group, and control group. Renal lesion and fibrosis, quantity of blood creatinine and urea nitrogen, and expression level of TGF-β1 and COX-2 in renal tissue were determined two weeks after the operation. Results: Two weeks after UUO, apparent renal lesion and fibrosis, raised level of blood creatinine and urea nitrogen, as well as upregulated expression of TGF-β1 and COX-2 were observed in both UUO and Par group, with significant differences from control group. There were also significant differences between group UUO and group Par in renal lesion and fibrosis, in blood creatinine and urea nitrogen level, and in TGF-β1 and COX-2 expression. Conclusions: Selective cyclooxygenase-2 inhibitor Parecoxib could reduce renal lesion and fibrosis on experimental UUO nephropathy.

Key words: Parecoxib, cyclooxygenase-2, ureteralobstruction, fibrosis