Abstract: Objective TO examine HOXA11, ER and PR expression in human endometrial hyperplasia and adenocarcinoma. Methods The immunohistochemistry were applied to analyze the level of HOXA11、ER and PR expression in the proliferative endometria.，simple hyperplasia and endometrial adenocarcinoma .Results The expression levels of HOXA11 in the endometrial hyperplasia and adenocarcinoma were significantly higher than that of proliferative endometrium (P<0.05). Compared with proliferative endometrium, the expressions of ER and PR in the endometrial hyperplasia and adenocarcinoma were decreased(P<0.05). Conclusion Overexpression of HOXA11, which is associated with the decreased expression of ER and PR, and loss of down-regulated HOXA11 by progestogen, may participate in the program of abnormal proliferation or adenocarcinoma of the endometrium.