基础医学与临床 ›› 2011, Vol. 31 ›› Issue (1): 104-107.

• 短篇综述 • 上一篇    下一篇

肿瘤恶病质的机制及可能的治疗

周开国,何桂珍   

  1. 北京协和医院
  • 收稿日期:2010-02-24 修回日期:2010-04-29 出版日期:2011-01-05 发布日期:2011-01-05
  • 通讯作者: 何桂珍

The mechanism of cancer cachexia and possible treatment

ZHOU Kai-guo ,HE Gui-zhen   

  1. PUMC Hospital, CAMS ﹠ PUMC
  • Received:2010-02-24 Revised:2010-04-29 Online:2011-01-05 Published:2011-01-05
  • Contact: HE Gui-zhen

摘要: 恶病质是宿主和肿瘤相互作用的结果,主要表现为短期内消瘦,营养不良等。宿主和肿瘤分泌的炎症因子和恶病质特异因子是引起恶病质的主要原因。单纯的高能饮食不能改善病情,近来应用免疫营养、传统医学和药物干预等防治手段能减轻恶病质体重下降和延长生存期,有可喜的应用前景。

关键词: 肿瘤恶病质, 机制, 治疗, 二十碳五烯酸, 预防

Abstract: Cachexia is the result of interaction between host and tumor,whose main manifestation are weight loss in short-term, malnutrition and so on.The inflammatory cytokines secreted by host and cachexia specific factor secreted by tumor are the main cause of cachexia . High-energy diet alone can not improve the condition. Recently, immunonutrition、traditional medicine and drug intervention can alleviate the weight loss and prolong survival in cachexia and thus has a promising prospect.