长链非编码RNA亚细胞定位和功能的研究进展

doi:10.16352/j.issn.1001-6325.2023.10.1580

基础医学与临床 ›› 2023, Vol. 43 ›› Issue (10): 1580-1584.doi: 10.16352/j.issn.1001-6325.2023.10.1580

长链非编码RNA亚细胞定位和功能的研究进展

苏越^1,2, 梁琳慧^1,2*, 何祥火^1,2*

1.复旦大学生物医学研究院,上海 200032;
2.复旦大学附属肿瘤医院肿瘤研究所,上海 200032

收稿日期:2023-02-27 修回日期:2023-04-11 出版日期:2023-10-05 发布日期:2023-10-05
通讯作者: *lianglinhui@fudan.edu.cn; xhhe@fudan.edu.cn
基金资助:
国家自然科学基金(81972253)

Research progress on subcellular localization and function of long non-coding RNA

SU Yue^{1, 2}, LIANG Linhui^{1, 2*}, HE Xianghuo^{1, 2*}

1. Institutes of Biomedical Sciences,Fudan University,Shanghai 200032;
2. Cancer Institute, Fudan University Shanghai Cancer Center, Shanghai 200032, China

Received:2023-02-27 Revised:2023-04-11 Online:2023-10-05 Published:2023-10-05
Contact: *lianglinhui@fudan.edu.cn; xhhe@fudan.edu.cn

摘要/Abstract

摘要： 长链非编码RNA(lncRNA)的亚细胞定位和其功能息息相关,定位于细胞核时,lncRNA可以维持染色质结构,调控基因转录,参与mRNA的可变剪接;定位于细胞质时参与信号传导、转录后调控、翻译和翻译后修饰;定位于细胞器时协助完成细胞器的功能。lncRNA的亚细胞定位机制与其自身序列、结合蛋白等密切相关。此外通过构建核滞溜载体Snovector、添加胞质定位元件等强制改变lncRNA的亚细胞定位,以及利用APEX2等技术研究lncRNA亚细胞定位和其功能之间的关系,有利于lncRNA疗法的开发。

关键词: 长链非编码RNA, 亚细胞定位, 长链非编码RNA功能

Abstract: The subcellular localization of long non-coding RNA(lncRNA) is closely related to its function. When localized in the nucleus, lncRNA can maintain chromatin structure, regulate gene transcription and participate in variable splicing of mRNA. When localized in the cytoplasm, lncRNA can mediate signal transduction, post-transcriptional regulation, translation and post-translational modification. When localized in the organelles, lncRNA can assist in the function of them. The subcellular localization of lncRNA is closely related to its own sequences and binding proteins. In addition, the development of lncRNA therapy will be facilitated by changing lncRNA subcellular localization in use of constructing Snovector, adding cytosolic localization elements, or techniques like APEX2, which indicates the relationship between the subcellular localization of lncRNA and its function.

Key words: long non-coding RNA, subcellular localization, function of long non-coding RNA

中图分类号:

苏越, 梁琳慧, 何祥火. 长链非编码RNA亚细胞定位和功能的研究进展[J]. 基础医学与临床, 2023, 43(10): 1580-1584.

SU Yue, LIANG Linhui, HE Xianghuo. Research progress on subcellular localization and function of long non-coding RNA[J]. Basic & Clinical Medicine, 2023, 43(10): 1580-1584.

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长链非编码RNA亚细胞定位和功能的研究进展

Research progress on subcellular localization and function of long non-coding RNA

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