11β-HSD1在炎性反应、肝癌的发生发展与免疫中作用的研究进展

doi:10.16352/j.issn.1001-6325.2023.05.0837

基础医学与临床 ›› 2023, Vol. 43 ›› Issue (5): 837-841.doi: 10.16352/j.issn.1001-6325.2023.05.0837

11β-HSD1在炎性反应、肝癌的发生发展与免疫中作用的研究进展

雷星煜¹, 冯雪松¹, 晁旭^1,2*

1.陕西中医药大学基础医学院,陕西咸阳 712046;
2.陕西中医药大学第二附属医院,陕西西安 712000

收稿日期:2022-12-12 修回日期:2023-03-21 出版日期:2023-05-05 发布日期:2023-04-26
通讯作者: ^*172665861@qq.com
基金资助:
陕西省中医药管理局科研项目(2021-zz-JC001);陕西省教育厅一般项目(20JK0588)

Progress on the role of 11β-HSD1 in inflammation,development of hepatocellular carcinoma and immunity

LEI Xingyu¹, FENG Xuesong¹, CHAO Xu^1,2*

1. College of Basic Medicine Sciences, Shaanxi University of Chinese Medicine, Xianyang 712046;
2. The Second Affiliated Hospital of Shaanxi University of Chinese Medicine, Xi'an 712000, China

Received:2022-12-12 Revised:2023-03-21 Online:2023-05-05 Published:2023-04-26
Contact: ^*172665861@qq.com

摘要/Abstract

摘要： 11β-羟基类固醇脱氢酶1(11β-HSD1)在与代谢有关的炎性疾病,以及免疫中可通过调节糖皮质激素(GC)的合成发挥抗炎或促炎作用。11β-HSD1的整体表达和活性可受促炎细胞因子的诱导,这一过程依赖于NF-κB信号通路并由其基因(HSD11B1)P1和P2启动子的利用水平最终决定。此外,11β-HSD1在肝细胞癌中通过降低葡萄糖摄入和糖酵解抑制肝细胞癌的增殖,并通过调节GC的水平参与胸腺中T细胞的发育和血管生成。了解11β-HSD1在炎性疾病、癌的发生发展、免疫中的分子调控机制有利于探究相关疾病的发生发展。

关键词: 11β-羟基类固醇脱氢酶(11β-HSD1), 炎性反应, 癌的发生发展, 免疫

Abstract: The 11β-hydroxysteroid dehydrogenase 1 (11β-HSD1) with anti-inflammatory or pro-inflammatory effects in inflammatory diseases is related to metabolism, as well as in the immune response through regulatpn of glucocorticoid (GC) synthesis. The expression and functional activity of 11β-HSD1 are potentially induced by pro-inflammatory cytokines, this process relies on the NF-κB signaling pathway and is ultimately determined by the utilization levels of HSD11B1 P1 and P2 promoters. In addition, 11β-HSD1 inhibits the proliferation of hepatocellular carcinoma by reducing glucose intake and glycolysis in hepatocellular carcinoma, and thus plays a role in the development of T cells in thymus and the form of angiogenesis by regulating the level of GC. Understanding the molecular regulatory mechanism of 11β-HSD1 in inflammatory diseases, carcinogenesis, development and immune response is conducive to exploring the occurrence and development of related diseases.

Key words: 11β-hydroxysteroid dehydrogenase 1(11β-HSD1), inflammation, carcinogenesis, immunity

中图分类号:

雷星煜, 冯雪松, 晁旭. 11β-HSD1在炎性反应、肝癌的发生发展与免疫中作用的研究进展[J]. 基础医学与临床, 2023, 43(5): 837-841.

LEI Xingyu, FENG Xuesong, CHAO Xu. Progress on the role of 11β-HSD1 in inflammation,development of hepatocellular carcinoma and immunity[J]. Basic & Clinical Medicine, 2023, 43(5): 837-841.

参考文献

[1]Chedid MF, Do NF, de Oliveira FS, et al. Interaction of HSD11B1 and H6PD polymorphisms in subjects with type 2 diabetes are protective factors against obesity: a cross-sectional study[J]. Diabetol Metab Syndr, 2019,11:78.doi: 10.1186/s13098-019-0474-2.
[2]Huang P, Li Y, Xu C, et al. HSD11B1 is upregulated synergistically by IFNγ and TNFα and mediates TSG-6 expression in human UC-MSCs[J].Cell Death Discov, 2020,6:24. doi: 10.1038/s41420-020-0262-7.
[3]Ballegeer M, Van Looveren K, Timmermans S, et al. Glucocorticoid receptor dimers control intestinal STAT1 and TNF-induced inflammation in mice[J]. J Clin Invest, 2018,128:3265-3279.
[4]Han D, Yu Z, Zhang H, et al. Microenvironment-associated gene HSD11B1 may serve as a prognostic biomarker in clear cell renal cell carcinoma: a study based on TCGA, RT-qPCR, Western blotting, and immunohistochemistry[J]. Bioengineered, 2021,12:10891-10904.
[5]Verma M, Kipari T, Zhang Z, et al. 11β-hydroxysteroid dehydrogenase-1 deficiency alters brain energy metabolism in acute systemic inflammation[J]. Brain Behav Immun,2018,69:223-234.
[6]Gomez-Sanchez EP, Gomez-Sanchez CE. 11β-hydroxysteroid dehydrogenases: a growing multi-tasking family[J]. Mol Cell Endocrinol,2021,526:111210. doi: 10.1016/j.mce.2021.111210.
[7]Lee NR, Kim BJ, Lee CH, et al. Role of 11β-hydroxysteroid dehydrogenase type 1 in the development of atopic dermatitis[J]. Sci Rep, 2020,10:20237.doi: 10.1038/s41598-020-77281-x.
[8]Oróstica L, Astorga I, Plaza-Parrochia F, et al. Proinflammatory environment and role of TNF-ɑ in endometrial function of obese women having polycystic ovarian syndrome[J]. Int J Obes (Lond), 2016,40:1715-1722.
[9]Hu M, Zhang Y, Guo X, et al. Perturbed ovarian and uterine glucocorticoid receptor signaling accompanies the balanced regulation of mitochondrial function and NFκB-mediated inflammation under conditions of hyperandrogenism and insulin resistance[J]. Life Sci, 2019, 232:116681. doi: 10.1016/j.lfs.2019.116681.
[10]李博然, 马璐璐, 申乐, 等. NF-κB信号通路在子宫内膜异位症疼痛中作用的研究进展[J]. 基础医学与临床,2018,38:4. doi: 10.3969/j.issn.1001-6325.2018.10.022.
[11]Thomas AE, Inagadapa P, Jeyapal S, et al. Maternal magnesium restriction elevates glucocorticoid stress and inflammation in the placenta and fetus of WNIN rat dams[J]. Biol Trace Elem Res, 2018,181:281-287.
[12]Verma M, Kipari T, Zhang Z, et al. 11β-hydroxysteroid dehydrogenase-1 deficiency alters brain energy metabolism in acute systemic inflammation[J]. Brain Behav Immun, 2018,69:223-234.
[13]Sattler J, Tu J, Stoner S, et al. Role of 11β-HSD type 1 in abnormal HPA axis activity during immune-mediated arthritis[J]. Endocr Connect, 2018,7:385-394.
[14]Vagnerová K, VodiŠka M, Hermanová P, et al. Interactions between gut microbiota and acute restraint stress in peripheral structures of the hypothalamic-pituitary-adrenal axis and the intestine of male mice[J]. Front Immunol, 2019,10:2655. doi: 10.3389/fimmu.2019.02655.
[15]Ergang P, Vagnerová K, Hermanová P, et al. The gut microbiota affects corticosterone production in the murine small intestine[J]. Int J Mol Sci, 2021,22:4229. doi: 10.3390/ijms22084229.
[16]Wu Y, Zhou BP. TNF-alpha/NF-kappaB/Snail pathway in cancer cell migration and invasion[J]. Br J Cancer, 2010,102:639-644.
[17]Liu X, Tan XL, Xia M, et al. Loss of 11βHSD1 enhances glycolysis, facilitates intrahepatic metastasis, and indicates poor prognosis in hepatocellular carcinoma[J]. Oncotarget, 2016,7:2038-2053.
[18]Wang C, Yu S, Qian R, et al. Prognostic and immunological significance of peroxisome proliferator-activated receptor gamma in hepatocellular carcinoma based on multiple databases[J]. Transl Cancer Res, 2022,11:1938-1953.
[19]Flannery PC, Abbott KL, Pondugula SR. Correlation of PPM1A downregulation with CYP3A4 repression in the tumor liver tissue of hepatocellular carcinoma patients[J]. Eur J Drug Metab Pharmacokinet, 2020,45:297-304.
[20]Khamis ZI, Pang X, Cui Z, et al. Cytochrome P450-2D6: a novel biomarker in liver cancer health disparity[J]. PLoS One, 2021,16:e257072. doi: 10.1371/journal.pone.0257072.
[21]Oliveira-de-Abreu E, Silva-Dos-Santos D, Lepletier A, et al. Lack of galectin-3 disrupts thymus homeostasis in association to increase of local and systemic glucocorticoid levels and steroidogenic machinery[J]. Front Endocrinol (Lausanne), 2018,9:365. doi: 10.3389/fendo.2018.00365.
[22]Rocamora-Reverte L, Reichardt HM, Villunger A, et al. T-cell autonomous death induced by regeneration of inert glucocorticoid metabolites[J]. Cell Death Dis, 2017,8:e2948. doi: 10.1038/cddis.2017.344.
[23]Zhang Z, Coutinho AE, Man TY, et al. Macrophage 11β-HSD-1 deficiency promotes inflammatory angiogenesis[J]. J Endocrinol, 2017,234:291-299.
[24]Wu J, Miller E, Davidson C, et al. Enhanced angiogen-esis by 11βHSD1 blockage is insufficient to improve reperfusion following hindlimb ischaemia[J]. Front Cardiovasc Med, 2021,8:795823. doi: 10.3389/fcvm.2021.795823.
[25]Shimada-Omori R, Yamasaki K, Koike S, et al. TLR3 augments glucocorticoid-synthetic enzymes expression in epidermal keratinocytes; implications of glucocorticoid metabolism in rosacea epidermis[J]. J Dermatol Sci, 2020,100:58-66.

11β-HSD1在炎性反应、肝癌的发生发展与免疫中作用的研究进展

Progress on the role of 11β-HSD1 in inflammation,development of hepatocellular carcinoma and immunity

PDF

可视化

摘要/Abstract

引用本文

使用本文

参考文献

相关文章 15

编辑推荐

Metrics

本文评价

[1]	季玮, 朱玥, 尧惠慈, 卢红艳. 白三烯C4及2型固有淋巴细胞在支气管肺发育不良中的变化及意义[J]. 基础医学与临床, 2023, 43(5): 711-716.
[2]	李珍, 段昭君, 罗云萍. 神经节苷脂GD2可作为肺癌干细胞一个潜在的候选标志物[J]. 基础医学与临床, 2023, 43(5): 777-784.
[3]	李高原, 王妍然, 王芳, 余佳. K562细胞中N-乙酰基转移酶10的RNA结合图谱分析[J]. 基础医学与临床, 2023, 43(5): 739-744.
[4]	孙莹, 杨治安, 何瑶, 余勤. HMGB1信号通路在支气管哮喘中作用的研究进展[J]. 基础医学与临床, 2023, 43(4): 690-694.
[5]	李立亚, 秦霈. 星形胶质细胞在中枢神经系统炎性疾病中作用的研究进展[J]. 基础医学与临床, 2023, 43(4): 665-668.
[6]	蒋烨, 余卓颖, 李民. 炎性反应在糖尿病神经病变发生中作用的研究进展[J]. 基础医学与临床, 2023, 43(4): 669-673.
[7]	王玉洁, 杨孟迪, 何风英, 丁雨露, 孙琳楠, 甄东户. 免疫调节基因的多态性与Graves病易感性的相关性研究进展[J]. 基础医学与临床, 2023, 43(3): 495-499.
[8]	张艺馨, 蔡善君, 李智立, 于伟泓, 张华. IgG N-糖基化修饰在糖尿病视网膜病变中作用的研究进展[J]. 基础医学与临床, 2023, 43(3): 509-513.
[9]	张上珠, 李清扬, 李海龙, 苏金梅, 李梦涛, 张文, 曾小峰. 风湿免疫科进修医师临床规范化培训模式初探[J]. 基础医学与临床, 2023, 43(3): 519-522.
[10]	刘芬, 胡润芳, 茅松, 徐敏, 石文静, 陈凌. 地塞米松减轻过敏性哮喘模型小鼠气道炎性反应[J]. 基础医学与临床, 2023, 43(3): 402-407.
[11]	秦玉春, 邝向东, 蔡林再, 谢景臣, 陈山. 双氢青蒿素减轻慢性阻塞性肺疾病(COPD)模型大鼠肺损伤[J]. 基础医学与临床, 2023, 43(3): 427-432.
[12]	施佳, 蔡成. 儿童复发性A族链球菌性扁桃体炎免疫机制的研究进展[J]. 基础医学与临床, 2023, 43(2): 336-340.
[13]	杨蕴钊, 石美涵, 周诚, 白雪源. 间充质干细胞在肾脏疾病治疗中的应用进展[J]. 基础医学与临床, 2023, 43(1): 30-37.
[14]	汪海燕, 韩钦, 赵春华. 间充质干细胞的免疫调节可塑性及其临床应用策略[J]. 基础医学与临床, 2023, 43(1): 2-11.
[15]	付士祥, 席月, 丁龙坤, 闫曼, 赵俊, 焦玉东, 吴亮. 鲍曼不动杆菌外膜囊泡诱发人单核-巨噬细胞THP-1的炎性反应[J]. 基础医学与临床, 2023, 43(1): 110-115.