内质网应激在骨关节炎中作用的研究进展

doi:10.16352/j.issn.1001-6325.2023.03.476

基础医学与临床 ›› 2023, Vol. 43 ›› Issue (3): 476-480.doi: 10.16352/j.issn.1001-6325.2023.03.476

内质网应激在骨关节炎中作用的研究进展

金涛^1,2, 杨青山², 吴树金³, 朱晓燕¹, 史宇悰¹, 牛建雄¹, 刘林^2*

1.甘肃中医药大学第一临床医学院,甘肃兰州 730000;
2.甘肃省人民医院骨科,甘肃兰州 730000;
3.兰州大学药学院,甘肃兰州 730000

收稿日期:2021-12-13 修回日期:2022-05-07 出版日期:2023-03-05 发布日期:2023-02-27
通讯作者: * 1120004990@qq.com
基金资助:
国家自然科学基金 (8176090197)

Research progress on the role of endoplasmic reticulum stress in osteoarthritis

JIN Tao^1,2, YANG Qingshan², WU Shujin³, ZHU Xiaoyan¹, SHI Yucong¹, NIU Jianxiong¹, LIU Lin^2*

1. The First Clinical College, Gansu University of Traditional Chinese Medicine, Lanzhou 730000;
2. Department of Orthopedics, Gansu Provincial People's Hospital, Lanzhou 730000;
3. School of Pharmacy, Lanzhou University, Lanzhou 730000, China

Received:2021-12-13 Revised:2022-05-07 Online:2023-03-05 Published:2023-02-27
Contact: * 1120004990@qq.com

摘要/Abstract

摘要： 骨关节炎是一种常见的关节退变性疾病,软骨细胞凋亡是其主要的病理生理改变,而内质网应激(ER stress)在其中发挥了不可忽视的作用。为了限制内质网应激带来的不利影响,细胞会激活未折叠蛋白质应答(UPR)。然而当内质网应激持续存在超过UPR所能承受的最大限度时,细胞会通过UPR的3条通路引发内质网功能障碍从而导致软骨细胞凋亡。

关键词: 骨关节炎, 软骨细胞凋亡, 内质网应激, 未折叠蛋白质应答

Abstract: Osteoarthritis is a common degenerative disease in which endoplasmic reticulum stress(ER stress) plays an important role in the pathogenesis of chondrocyte apoptosis. To limit the adverse effects of endoplasmic reticulum stress, cells activate the unfolded protein response (UPR). However, when endoplasmic reticulum stress persists beyond the maximum tolerance of UPR, cells may trigger endoplasmic reticulum dysfunction through three pathways of UPR leading to chondrocyte apoptosis.

Key words: osteoarthritis, chondrocyte apoptosis, endoplasmic reticulum stress, unfolded protein response

中图分类号:

R684.3

金涛, 杨青山, 吴树金, 朱晓燕, 史宇悰, 牛建雄, 刘林. 内质网应激在骨关节炎中作用的研究进展[J]. 基础医学与临床, 2023, 43(3): 476-480.

JIN Tao, YANG Qingshan, WU Shujin, ZHU Xiaoyan, SHI Yucong, NIU Jianxiong, LIU Lin. Research progress on the role of endoplasmic reticulum stress in osteoarthritis[J]. Basic & Clinical Medicine, 2023, 43(3): 476-480.

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内质网应激在骨关节炎中作用的研究进展

Research progress on the role of endoplasmic reticulum stress in osteoarthritis

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