基础医学与临床 ›› 2022, Vol. 42 ›› Issue (8): 1274-1278.doi: 10.16352/j.issn.1001-6325.2022.08.1274

• 短篇综述 • 上一篇    下一篇

RNA结合基序蛋白家族介导的可变剪接在心肌疾病中的研究进展

刘述1,2, 丁虹1, 赵可心1,2, 白锋1, 张小卫1*   

  1. 1.兰州大学第二医院 心血管内科; 2.兰州大学 第二临床医学院; 甘肃 兰州 730030
  • 收稿日期:2021-03-18 修回日期:2021-08-24 出版日期:2022-08-05 发布日期:2022-08-02
  • 通讯作者: *zhangxw727@163.com
  • 基金资助:
    国家自然科学基金(82060080);甘肃省科技计划项目(20YF3WA016);甘肃省高等学校创新基金项目(2020B-024);甘肃省心脏康复工程研究中心(CRQI-C00535)

Research progress of RNA binding motif protein family-mediated alternative splicing in cardiomyopathy

LIU Shu1,2, DING Hong1, ZHAO Ke-xin1,2, BAI Feng1, ZHANG Xiao-wei1*   

  1. 1. Department of Cardiology, the Second Hospital of Lanzhou University; 2. the Second Clinical Medical College of Lanzhou University, Lanzhou 730030, China
  • Received:2021-03-18 Revised:2021-08-24 Online:2022-08-05 Published:2022-08-02
  • Contact: *zhangxw727@163.com

摘要: RNA结合基序蛋白(RBM)是RNA结合蛋白中的一类,均含有RNA识别基序、RNA结合基序以及核糖核蛋白基序。RBM家族成员介导的可变剪接与心肌收缩蛋白、心肌发育及心肌细胞钠离子通道等息息相关,从而在心肌疾病,乃至心力衰竭中发挥重要的作用。

关键词: RNA结合基序蛋白, 可变剪接, 心肌病

Abstract: RNA binding motif protein (RBM) is a type of RNA binding protein, which contains RNA recognition motif, RNA binding motif and ribo-nucleo-protein motif. The alternative splicing mediated by members of the RBM family is closely related to myocardial contractile proteins, myocardial development and myocardial sodium channels, which play an important role in pathogenesis of myocardial diseases and even heart failure.

Key words: RNA binding motif protein, alternative splicing, cardiomyopathy

中图分类号: