雪旺细胞促进周围神经再生机制的研究进展

doi:10.16352/j.issn.1001-6325.2022.01.020

基础医学与临床 ›› 2022, Vol. 42 ›› Issue (1): 145-148.doi: 10.16352/j.issn.1001-6325.2022.01.020

雪旺细胞促进周围神经再生机制的研究进展

杨溢铎, 国海东, 邵水金^*, 刘玉璞

上海中医药大学基础医学院人体解剖学教研室,上海 201203

收稿日期:2020-11-27 修回日期:2021-05-06 出版日期:2022-01-05 发布日期:2022-01-05
通讯作者: ^* shaoshuijin@163.com
基金资助:
国家自然科学基金(8187150017)

Research progress on mechanism of Schwann cells promoting peripheral nerve regeneration

YANG Yi-duo, GUO Hai-dong, SHAO Shui-jin^*, LIU Yu-pu

Department of Human Anatomy,School of Basic Medicine,Shanghai University of Traditional Chinese Medicine, Shanghai 201203,China

Received:2020-11-27 Revised:2021-05-06 Online:2022-01-05 Published:2022-01-05
Contact: ^* shaoshuijin@163.com

摘要/Abstract

摘要： 雪旺细胞(SCs)具有强大的可塑性。周围神经损伤后,雪旺细胞去分化为修复表型,主导了修复过程。c-Jun氨基末端激酶、有丝分裂原激活的蛋白激酶(MAPK)等多种信号通路和转录调节因子参与调控雪旺细胞介导的修复程序。本综述讨论了雪旺细胞促进周围神经再生的主要信号通路与转录调节因子。

关键词: 周围神经, 雪旺细胞, 信号通路, 神经再生, 修复机制

Abstract: Schwann cells (SCs) have a strong plasticity. After peripheral nerve injury, Schwann cells dedifferentiate into repair phenotype and dominate the repair process. C-Jun N-terminal kinase, mitogen activated protein kinase(MAPK) and other signaling pathways and transcriptional regulators are involved in regulating Schwann cell-mediated repair process. This review discusses the main signaling pathways and transcriptional regulators of Schwann cell promoting peripheral nerve regeneration.

Key words: peripheral nerve, Schwann cells, signal pathway, nerve regeneration, repair mechanism

中图分类号:

杨溢铎, 国海东, 邵水金, 刘玉璞. 雪旺细胞促进周围神经再生机制的研究进展[J]. 基础医学与临床, 2022, 42(1): 145-148.

YANG Yi-duo, GUO Hai-dong, SHAO Shui-jin, LIU Yu-pu. Research progress on mechanism of Schwann cells promoting peripheral nerve regeneration[J]. Basic & Clinical Medicine, 2022, 42(1): 145-148.

参考文献

[1]Gomez-Sanchez J, Pilch K, Vander L, et al. After nerve injury, lineage tracing shows that myelin and remak sch-wann cells elongate extensively and branch to form repair Schwann cells, which shorten radically on remyelination[J]. Neurosci, 2017, 37: 9086-9099.
[2]Vaquié A, Sauvain A, Duman M, et al. Injured axons instruct Schwann cells to build constricting actin spheres to accelerate axonal disintegration[J]. Cell Rep, 2019, 27: 3152-3166.
[3]Wilcox M, Laranjeira S, Eriksson T,et al. Characterising cellular and molecular features of human peripheral nerve degeneration[J].Acta Neuropathol Commun, 2020,17:51-68.
[4]Li Y, Song F, Zhong K,et al. Pre-Injection of small interfering RNA (siRNA) promotes c-Jun gene silencing and decreases the survival rate of axotomy-injured spinal motoneurons in adult mice[J]. Mol Neurosci, 2018,65:400-410.
[5]Sowa Y,Kishida T,Tomita K,et al. Direct conversion of human fibroblasts into Schwann cells that facilitate regeneration of injured peripheral nerve in vivo[J].Stem Cells Transl Med,2017,6:1207-1216.
[6]Cervellini I, Galino J, Zhu N, et al.Sustained MAPK/ERK activation in adult Schwann cells impairs nerve repair[J]. Neurosci, 2018,38:679-690.
[7]Hausott B, Klimaschewski L. Promotion of peripheral nerve regeneration by stimulation of the extracellular signal-regulated kinase (ERK) pathway[J]. Anat Rec, 2019, 302:1261-1267.
[8] Jiang X, Wang Y, Zhang B, et al. Acetyl-11-keto-β-boswellic acid regulates the repair of rat sciatic nerve injury by promoting the proliferation of Schwann cells[J]. Life Sci, 2020, 254:116887-116902.
[9]Ko K, Lee J, Lee D, et al. Hepatocyte Growth Factor (HGF) promotes peripheral nerve regeneration by activat-ing repair Schwann cells[J]. Sci Rep, 2018, 8:8316-8330.
[10]Liu D, Jia S, Sun D, et al. Rapamycin repairs damaged nerve cells and neurological function in rats with spinal cord injury through ERK signaling pathway[J].Biol Regul Homeost Agents,2020,34:865-873.
[11]Xu H, Wang P, Sun Y, et al. Activation of neuregulin 1/ErbB signaling is involved in the development of TOCP-induced delayed neuropathy [J]. Front Mol Neurosci, 2018,11:129-144.
[12]Reed C, Frick L, Weaver A, et al. Deletion of calcineurin in Schwann cells does not affect developmental myelination, but reduces autophagy and delays myelin clearance after peripheral nerve injury[J]. Neurosci, 2020, 40: 6165-6176.
[13]Lee Y, Li Y, Mikesh M, et al. Neuregulin1 displayed on motor axons regulates terminal Schwann cell-mediated synapse elimination at developing neuromuscular junctions[J].Proc Natl Acad Sci U S A, 2016,113:479-487.
[14]Longo J, Brosius S, Black L, et al. ErbB4 promotes malignant peripheral nerve sheath tumor pathogenesis via Ras-independent mechanisms[J]. Cell Commun Signal, 2019,17:74-93.
[15]Ammoun S, Provenzano L, Zhou L, et al. Axl/Gas6/NFκB signalling in schwannoma pathological proliferation, adhesion and survival[J]. Oncogene, 2014, 33: 336-346.
[16]Dong L, Li R, Li D, et al. FGF10 enhances peripheral nerve regeneration the preactivation of the PI3K/Akt signaling-mediated antioxidant response[J].Front Pharmacol, 2019, 10: 1224-1237.
[17]简宇, 代凌云, 吴丰学. 白藜芦醇减轻脑创伤大鼠炎性反应及神经元凋亡[J]. 基础医学与临床, 2020, 40:1631-1635.

雪旺细胞促进周围神经再生机制的研究进展

Research progress on mechanism of Schwann cells promoting peripheral nerve regeneration

PDF

可视化

摘要/Abstract

引用本文

使用本文

参考文献

相关文章 15

编辑推荐

Metrics

本文评价

[1]	蒲超, 张珊珊, 吴青霞, 罗栩伟, 王亮, 张波. Lnc000727促进人骨髓间充质干细胞向成骨细胞分化[J]. 基础医学与临床, 2022, 42(7): 1047-1052.
[2]	谢兴文, 钟建春, 李鼎鹏, 黄睿, 李宁, 郭云龙, 翟伯宇. 薯蓣皂苷防治原发性骨质疏松的研究进展[J]. 基础医学与临床, 2022, 42(6): 960-963.
[3]	陈勇, 庞红利, 许远征, 毛珊珊, 洪道先. 氯胺酮减轻大鼠脊髓缺血/再灌注损伤[J]. 基础医学与临床, 2022, 42(4): 622-627.
[4]	李蓉, 朱含月. 酮咯酸氨丁三醇抑制膝骨关节炎模型大鼠炎性反应[J]. 基础医学与临床, 2022, 42(3): 417-422.
[5]	杨芒庄, 杨旭东, 王晓龙. Circ-MALAT1靶向miR-101抑制膀胱癌细胞系SW780侵袭和迁移[J]. 基础医学与临床, 2022, 42(3): 472-478.
[6]	牛世伟, 苏韫, 龚红霞, 李婷婷, 曾元丁, 张晗, 聂蓬. 胃癌患者血清IL-1的升高和癌组织JAK2/STAT3信号通路的激活[J]. 基础医学与临床, 2022, 42(3): 401-405.
[7]	陈茜, 刘宪, 崔南, 翟阳. 敲除EZH2抑制人宫颈癌细胞系迁移和侵袭[J]. 基础医学与临床, 2022, 42(3): 395-400.
[8]	邓九红, 郑超, 王声遥, 王心怡. 醋酸泼尼松对糖尿病肾病模型大鼠肾功能、肾脏炎性反应及AMPK/SIRT1信号通路的影响[J]. 基础医学与临床, 2022, 42(2): 243-248.
[9]	李勇晓, 孙燕, 张瑞生. 丙泊酚抑制人子宫内膜癌细胞系RL95-2增殖[J]. 基础医学与临床, 2022, 42(1): 114-119.
[10]	生燕李秀毛郭欣谢仟黄仁杰生欣. 兔颈动脉血流灌注减少促进血管内皮细胞炎性反应[J]. 基础医学与临床, 2021, 41(9): 1247-1252.
[11]	秦建民张来香魏振英. miR-193a-3p抑制高糖诱导人视网膜血管内皮细胞凋亡[J]. 基础医学与临床, 2021, 41(7): 995-1000.
[12]	陈建苗. DFG-STYK1/NOK对小鼠胚胎成纤维细胞系NIH3T3增殖以及细胞周期G1/S的影响[J]. 基础医学与临床, 2021, 41(6): 859-864.
[13]	刘高澳彭小忠舒鹏程. Dicer1缺失对小鼠早期神经发育的影响[J]. 基础医学与临床, 2021, 41(6): 818-824.
[14]	边芳李宁李奇李康金雯. 膜联蛋白A1减轻1型糖尿病小鼠微血管并发症[J]. 基础医学与临床, 2021, 41(4): 484-489.
[15]	李玉婷罗乐尹素娟朱小兰. 丹酚酸B减轻LPS诱导的小鼠急性肺损伤[J]. 基础医学与临床, 2021, 41(3): 376-381.