基础医学与临床 ›› 2018, Vol. 38 ›› Issue (10): 1461-1465.
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吴剑平,肖海英,郑雪莲,汪安江
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摘要： 白介素25（IL-25）是白介素17家族成员之一,在慢性炎症反应和肿瘤中具有重要作用。IL-25能够活化肝星状细胞并且可以诱导下游促纤维化细胞因子IL-4、IL-13的表达；IL-25可以促进M2型巨噬细胞极化并且可能会招募LY-6Clo单核细胞来源的巨噬细胞分化，而M2型巨噬细胞和LY-6Clo单核细胞来源的巨噬细胞都是抗肝纤维化细胞。可见IL-25及其相关因素与肝纤维化的关系还不甚清楚。
关键词: 白介素25, 巨噬细胞, 肝纤维化
Abstract: Interleukin 25 (IL-25) is a member of the IL-17 family and plays an important role in chronic inflammation and cancer. IL-25 can activate hepatic stellate cells and induce the expression of downstream cytokines IL-4 and IL-13, which promote liver fibrosis; IL-25 can promote M2 Macrophages polarization and maybe can recruit LY-6Clo infiltrating macrophages, which inhibit liver fibrosis, Therefore, the relationship between IL-25 and its related factors with liver fibrosis is yet unclear.
Key words: Interleukin 25, Macrophages, Liver fibrosis
吴剑平 肖海英 郑雪莲 汪安江. 白介素25及其相关因子在肝纤维化中的作用[J]. 基础医学与临床, 2018, 38(10): 1461-1465.
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http://journal11.magtechjournal.com/Jwk_jcyxylc/CN/Y2018/V38/I10/1461
