基础医学与临床 ›› 2016, Vol. 36 ›› Issue (1): 112-115.
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刘会可,许海燕
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摘要: AXL是酪氨酸激酶受体之一,在恶性肿瘤细胞中高表达,并通过多种信号转导途径,尤其是与EMT形成正向反馈循环,促进肿瘤转移和耐药,成为肿瘤治疗的一个新靶点。通过抑制AXL的表达可有效逆转EMT和肿瘤转移与耐药。
关键词: 关键词:AXL, 癌细胞, 迁移, 浸润, 耐药
Abstract: The receptor tyrosine kinase (RTK) AXL is over expressed in multiple tumor cells and mediates the metastasis and drug resistance of tumor cells through a variety of signaling pathways, especially form positive feedback loops with EMT, therefore has become a new tumor therapeutic target. By inhibiting the expression of AXL can effectively reverse EMT and tumor metastasis and drug-resistance.
Key words: Key words: AXL, cancer cell, metastasis, invasion, drug resistance
中图分类号:
R73
刘会可 许海燕. AXL在肿瘤转移和耐药中的作用及干预策略研究进展[J]. 基础医学与临床, 2016, 36(1): 112-115.
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