基础医学与临床 ›› 2015, Vol. 35 ›› Issue (1): 122-125.
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左晖1,沈悦海2,郭晓汐2,王冠林2,张宽仁2
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摘要: 肿瘤是一种系统生物学疾病,治疗这一顽固疾病仅靠单一靶向药物已不太现实。本文将用系统生物学的观点,对肿瘤坏死因子相关凋亡配体(TRAIL)与现今研究较热点的靶向药物以网络“network”联合方式,协同抗肿瘤进行一个综述。以期待为基于TRAIL个体化治疗肿瘤提供夯实的理论依据。
关键词: TRAIL, 网络靶向, 肿瘤, 研究进展
Abstract: Tumor is a systems biology disease. Treating this intractable disease by single targeted drugs has not been realistic. In this review, we analyze the anti-tumor network of Tumor Necrosis Factor-related Apoptosis-inducing Ligand(TRAIL) by a systems biology perspective, and look forward to providing individualized treatment theory in hospital based on TRAIL.
Key words: TRAIL, Network Targeting therapy, Tumor, Research review
左晖 沈悦海 郭晓汐 王冠林 张宽仁. 系统生物学指导下基于TRAIL网络靶向抗肿瘤研究进展[J]. 基础医学与临床, 2015, 35(1): 122-125.
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