基础医学与临床 ›› 2014, Vol. 34 ›› Issue (11): 1582-1585.
• 短篇综述 • 上一篇 下一篇
张冰清1,张昀1,曾学军2
收稿日期:
修回日期:
出版日期:
发布日期:
通讯作者:
Received:
Revised:
Online:
Published:
Contact:
摘要： 肾小管上皮细胞存在多种尿酸转运相关蛋白，按照功能不同可分为重吸收相关蛋白、排泄相关蛋白和骨架蛋白。尿酸盐转运子1、葡萄糖转运子9和ATP结合盒蛋白家族G蛋白亚家族成员2是最重要的尿酸转运蛋白；PDZK1为其他蛋白提供结构支持。这些尿酸转运蛋白是高尿酸血症和其他代谢紊乱的纽带，也是新型降尿酸药物的研究靶点。
关键词: 尿酸, 尿酸转运蛋白, 降尿酸治疗
Abstract: Renal proximal epithelial cells contain multiple urate transporters, which could be categorized into reabsorption related, excretion related and skeleton proteins by function. Urate transporter 1, glucose transporter 9 and ATP-binding cassette family G subfamily type 2 are the three most important transporters; while PDZK1 provides structural support for other transporters. These urate transporters are the linkage of hyperuricemia and other metabolic disorders, as well as the promising target of new urate lowering therapies.
Key words: urate, urate transporter, urate-lowering therapy
张冰清 张昀 曾学军. 尿酸转运蛋白是治疗高尿酸血症的新靶点[J]. 基础医学与临床, 2014, 34(11): 1582-1585.
0 / / 推荐
导出引用管理器 EndNote|Reference Manager|ProCite|BibTeX|RefWorks
链接本文: http://journal11.magtechjournal.com/Jwk_jcyxylc/CN/
http://journal11.magtechjournal.com/Jwk_jcyxylc/CN/Y2014/V34/I11/1582
