中国囊性纤维化患者单中心焦虑抑郁状况调查

doi:10.16352/j.issn.1001-6325.2023.04.0647

基础医学与临床 ›› 2023, Vol. 43 ›› Issue (4): 647-650.doi: 10.16352/j.issn.1001-6325.2023.04.0647

中国囊性纤维化患者单中心焦虑抑郁状况调查

周王继^#, 孙艳艳^#, 程重生, 赵阳, 韩江娜, 戴金荣, 孟淑珍, 徐凯峰, 田欣伦^*

中国医学科学院北京协和医学院北京协和医院疑难重症及罕见病国家重点实验室呼吸与危重症医学科,北京 100730

收稿日期:2022-04-29 修回日期:2022-06-28 出版日期:2023-04-05 发布日期:2023-04-03
通讯作者: ^*tianxl@pumch.cn
作者简介:^#对本文有相同贡献
基金资助:
中国医学科学院临床与转化医学研究基金(2020-I2M-C&T-B-002);国家重点研发计划(2016YFC0901500);中国医学科学院医学与健康科技创新工程项目(CIFMS 2021-I2M-1-003)

A single center survey of anxiety and depression status in Chinese cystic fibrosis patients

ZHOU Wangji^#, SUN Yanyan^#, CHENG Chongsheng, ZHAO Yang, HAN Jiangna, DAI Jinrong, MENG Shuzhen, XU Kaifeng, TIAN Xinlun^*

Department of Respiratory and Critical Care Medicine, State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100730, China

Received:2022-04-29 Revised:2022-06-28 Online:2023-04-05 Published:2023-04-03
Contact: ^*tianxl@pumch.cn

摘要/Abstract

摘要： 目的研究中国囊性纤维化(CF)患者合并焦虑抑郁情况。方法收集并分析北京协和医院CF注册登记队列研究中28例患者的临床资料,使用综合医院焦虑/抑郁情绪测定表评估CF合并焦虑抑郁患病状况。结果男性患者占42.9%(12/28),平均年龄(23±4.8)岁。检出焦虑或抑郁14例(50%),其中,中重度焦虑或抑郁8例(28.6%),中重度焦虑5例(17.9%),中重度抑郁7例(25.0%),严重焦虑1例(3.6%),无严重抑郁患者,4例患者(14.3%)同时存在中重度焦虑和中重度抑郁。与单纯CF患者相比,CF合并焦虑患者的肺通气功能更差,表现为FVC% pred(合并焦虑54.5%±18.8%,单纯CF 80.0%±14.6%,P＜0.05)显著下降。CF合并抑郁患者的肺通气功能同样更差,表现为FEV₁% pred(合并抑郁41.6%±21.6%,单纯CF 64.2%±20.9%,P＜0.05)及FVC% pred(合并抑郁53.9%±21.0%,单纯CF 80.0%±14.6%,P＜0.01)显著下降。结论半数CF患者合并焦虑或抑郁,焦虑与抑郁共病率较高,严重焦虑或抑郁患病率低。与单纯CF患者相比,合并焦虑或抑郁的CF患者肺通气功能更差。

关键词: 焦虑, 抑郁, 综合医院焦虑抑郁量表, 囊性纤维化

Abstract: Objective To study anxiety and depression in Chinese patients with cystic fibrosis (CF). Methods Clinical data from 28 CF patients in the cystic fibrosis registry study of Peking Union Medical College Hospital were collected and analyzed. Hospital anxiety and depression scale was used to identify anxiety and depression. Results The cohort had 42.9% (12/28) males with a mean age of 23±4.8 years. 14 patients (50%) had anxiety or depression. Among them, 8 subjects (28.6%) had moderate and severe anxiety or depression, and 5 patients (17.9%) were with moderate and severe anxiety, and 7 patients(25%) with moderate and severe depression. One patient(3.6%) had severe anxiety, no patients with severe depression, and four patients (14.3%) had both moderate and severe anxiety and depression. Compared to patients without anxiety or depression, patients with anxiety had significantly lower FVC% pred (54.5%±18.8% with anxiety, 80.0%±14.6% without anxiety or depression, P＜0.05), and patients with depression had significantly lower FEV₁% pred (41.6%±21.6% with depression, 64.2%±20.9% without anxiety or depression, P＜0.05) and FVC% pred (53.9%±21.0% with depression, 80.0%±14.6% without anxiety or depression, P＜0.01). Conclusions Half of CF patients have anxiety or depression, with a high comorbidity rate of anxiety and depression and a low prevalence of severe anxiety or depression in our cohort. CF patients with anxiety or depression have worse pulmonary ventilationy function compared to CF patients without anxiety or depression.

Key words: anxiety, depression, hospital anxiety and depression scale, cystic fibrosis

中图分类号:

R562

周王继, 孙艳艳, 程重生, 赵阳, 韩江娜, 戴金荣, 孟淑珍, 徐凯峰, 田欣伦. 中国囊性纤维化患者单中心焦虑抑郁状况调查[J]. 基础医学与临床, 2023, 43(4): 647-650.

ZHOU Wangji, SUN Yanyan, CHENG Chongsheng, ZHAO Yang, HAN Jiangna, DAI Jinrong, MENG Shuzhen, XU Kaifeng, TIAN Xinlun. A single center survey of anxiety and depression status in Chinese cystic fibrosis patients[J]. Basic & Clinical Medicine, 2023, 43(4): 647-650.

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中国囊性纤维化患者单中心焦虑抑郁状况调查

A single center survey of anxiety and depression status in Chinese cystic fibrosis patients

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