基础医学与临床 ›› 2022, Vol. 42 ›› Issue (1): 145-148.

• 短篇综述 • 上一篇    下一篇

雪旺细胞促进周围神经再生机制的研究进展

杨溢铎,国海东,邵水金,刘玉璞   

  1. 上海中医药大学
  • 收稿日期:2020-11-27 修回日期:2021-04-29 出版日期:2022-01-05 发布日期:2022-01-05
  • 通讯作者: 邵水金 E-mail:shaoshuijin@163.com
  • 基金资助:
    外泌体介导的miR-21传递参与电针促进大鼠坐骨神经损伤后修复的研究

Research progress on mechanism of Schwann cells promoting peripheral nerve regeneration

  • Received:2020-11-27 Revised:2021-04-29 Online:2022-01-05 Published:2022-01-05
  • Supported by:
    Exosome mediated miR-21 transmission participates in electroacupuncture promoting the repair of sciatic nerve after injury in rats

摘要: 雪旺细胞(SCs)具有强大的可塑性。周围神经损伤后,雪旺细胞去分化为修复表型,主导了修复过程。c-Jun氨基末端激酶、有丝分裂原激活的蛋白激酶等多种信号通路和转录调节因子参与调控雪旺细胞介导的修复程序,在这篇综述中,我们讨论了雪旺细胞促进周围神经再生的主要信号通路与转录调节因子。

关键词: 周围神经, 雪旺细胞, 信号通路, 神经再生, 修复机制

Abstract: Schwann cells (SCs) have strong plasticity. After peripheral nerve injury, Schwann cells dedifferentiate into repair phenotype and dominate the repair process. C-Jun N-terminal kinase, mitogen activated protein kinase and other signaling pathways and transcriptional regulators are involved in regulating Schwann cell-mediated repair process. In this review, we discuss the main signaling pathways and transcriptional regulators of Schwann cell promoting peripheral nerve regeneration.

Key words: peripheral nerve, Schwann cells, signal pathway, nerve regeneration, repair mechanism