基础医学与临床 ›› 2021, Vol. 41 ›› Issue (8): 1169-1173.

• 临床研究 • 上一篇    下一篇

运动认知风险综合征增加老年人住院风险

袁景林1, 赵瑞雪2, 李晓东2, 蒋晓燕3, 王笑峰4, 周晓梅1, 李淑娟2*   

  1. 1.大兴区人民医院 神经内科, 北京 102600;
    2.首都医科大学附属北京朝阳医院 神经内科, 北京 100020;
    3.同济大学医学院 病理学与病理生理学系, 上海 200092;
    4.复旦大学人类表型组研究院 现代人类学教育部重点实验室,上海 200433
  • 收稿日期:2021-02-20 修回日期:2021-05-24 出版日期:2021-08-05 发布日期:2021-07-21
  • 通讯作者: *2431965@qq.com
  • 基金资助:
    国家重点研发计划(2018YFC2000400,2018YEC2002000);国家自然科学基金(81971102)

Motoric cognitive risk syndrome increases the risk of hospitalization in the elderly

YUAN Jing-lin1, ZHAO Rui-xue2, LI Xiao-dong2, JIANG Xiao-yan3, WANG Xiao-feng4, ZHOU Xiao-mei1, LI Shu-juan2*   

  1. 1. Department of Neurology, Daxing District People's Hospital, Beijing 102600;
    2. Department of Neurology, Beijing Chao-Yang Hospital, Capital Medical University, Beijing 100020;
    3. Department of Pathology and Pathophysiology, Tongji University School of Medicine, Shanghai 200092;
    4. Ministry of Education Key Laboratory of Contemporary Anthropology, Human Phenome Institute, Fudan University, Shanghai 200433, China
  • Received:2021-02-20 Revised:2021-05-24 Online:2021-08-05 Published:2021-07-21
  • Contact: *2431965@qq.com

摘要: 目的 探讨中国老年人运动认知风险综合征的流行病学特征及其和住院的关系。方法 用如皋长寿和衰老研究的子队列,通过简版老年抑郁量表(GDS-15)评估是否存在主观记忆抱怨,通过起立-行走计时试验(TUGT)评估是否存在步速缓慢,两者同时存在判定为MCR。记录研究对象从2014年基线调查至2017年第2次随访3年期间的住院发生情况,比较 “住院”和“非住院”组MCR发生情况,分析MCR和住院的关联。结果 本次研究1 076例研究对象,平均年龄(75.0±3.8)岁; MCR的患病率为3.3%,在3年随访期间MCR组有61.1%发生住院,高于非MCR组的41.9%(P<0.05);住院组平均年龄更高,男性、非文盲、患有高血压、糖尿病、脑血管疾病者的比例更高。住院组合并MCR的比例为4.8%,高于非住院组的2.3%(P<0.05)。在调整年龄、性别、职业、受教育程度、婚姻状况、吸烟状况、BMI、高血压、糖尿病和冠心病病史、脑血管病史等混杂因素后,MCR与老年人住院风险增加相关(P<0.05)。结论 高龄、男性、患有高血压、糖尿病以及脑血管病史的老年人,住院的发生率更高,且MCR与住院发生显著相关。

关键词: 认知障碍, 住院, 老年人, 队列研究

Abstract: Objective To explore the epidemiological characteristics of motoric cognitive risk syndrome (MCR) in Chinese elderly and its relationship with hospitalization. Methods Data were collected from a subcohort of the rugao longevity and aging study. Subjective memory complaints were assessed by the geriatric depression scale (GDS-15), and slow gait was assessed by the time up and go test (TUGT). MCR was determined by the presence of both. The incidence of hospitalization was recorded from the baseline survey in 2014 to the second 3-year follow-up in 2017, and the incidence of MCR in the hospitalized and non-hospitalized groups was compared to analyze the association between MCR and hospitalization. Results In this study, 1 076 subjects were enrolled, with an average age of 75.0±3.8 years old; The prevalence of MCR was 3.3%. During the 3-year follow-up period, 61.1% of the MCR group had records of hospitalization, while only 41.9% of the non-MCR group had the record of hospitalization (P<0.05). The hospitalized group had a higher average age, and a higher proportion of men, non-illiterates, and those with hypertension, diabetes, and cerebrovascular disease. Hospital combination and the proportion of MCR is 4.8%, the hospital group was 2.3% (P<0.05). After adjusting for age, sex, occupation, level of education, marital status, smoking status, BMI, blood pressure, diabetes and coronary heart disease, cerebrovascular disease, and other confounding factors, MCR is associated with increased risk of hospitalization in the elderly (P<0.05). Conclusions The incidence of hospitalization was higher in the population of male especiall those with hypertension, diabetes and cerebrovascular history, MCR is significantly associated with hospitalization.

Key words: cognitive impairment, hospitalization, elderly, cohort study

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