核干细胞因子主导的信号通路影响肿瘤发生发展的研究进展

基础医学与临床 ›› 2020, Vol. 40 ›› Issue (4): 547-551.

核干细胞因子主导的信号通路影响肿瘤发生发展的研究进展

贺振华^1*, 沈富辉^1,2, 曾凡钢², 刘千琳², 袁静敏¹

兰州大学第二临床医学院/兰州大学第二医院 1.神经外科;
2.临床医学系,甘肃兰州 730000

收稿日期:2019-07-11 修回日期:2019-12-03 出版日期:2020-04-05 发布日期:2020-04-06
通讯作者: *changlang911@126.com
基金资助:
甘肃省自然科学基金(17JR5RA241);国家级大学生创新创业训练计划项目(201910730218);兰州大学第二临床医学院萃英学子科研培育计划(CYXZ-37)

Research progress of nucleostemin signaling pathway in tumorigenesis and development

HE Zhen-hua^1*, SHEN Fu-hui^1,2, ZENG Fan-gang², LIU Qian-lin², YUAN Jing-min¹

1. Department of Neurosurgery;
2. Department of Clinical Medicine, Lanzhou University Second Hospital, Lanzhou University Second Clinical College, Lanzhou 730000, China

Received:2019-07-11 Revised:2019-12-03 Online:2020-04-05 Published:2020-04-06
Contact: *changlang911@126.com

摘要/Abstract

摘要： 沉默核干细胞因子(NS)会激活p53依赖途径,p53通过磷脂酰肌醇-3羟基激酶(PI3K)/蛋白激酶B(PKB,又称AKT)/哺乳动物雷帕霉素靶蛋白(mTOR)信号通路抑制肿瘤细胞增殖。低表达的NS也能通过非p53依赖途径抑制PI3K/AKT/mTOR信号通路。抑制p53可以激活Wnt/β-catenin信号通路。NS高表达也会激活Wnt/β-catenin信号通路。c-Myc的过表达可使NS高表达,也可抑制p53表达,促进细胞增殖。

关键词: 核干细胞因子, 基因, 蛋白, 信号通路

Abstract: Silencing nucleostemin (NS) can activate the p53 pathway and p53 inhibit proliferation of the tumor cell through the phosphatidylinositol 3-kinase (PI3K)/ protein kinase B (PKB or AKT)/ mammalian target of rapamycin (mTOR) signal pathway. Low expression of NS also inhibits the PI3K/AKT/mTOR signal pathway through a non-p53 pathway. Inhibition of p53 activates the Wnt/β-catenin signal pathway. High expression of NS also activates the Wnt/β-catenin signal pathway. Over-expression of c-Myc increases NS expression and inhibits p53 expression,which may promote cell proliferation.

Key words: nucleostemin(NS), gene, protein, signal pathway

中图分类号:

R730.231

贺振华, 沈富辉, 曾凡钢, 刘千琳, 袁静敏. 核干细胞因子主导的信号通路影响肿瘤发生发展的研究进展[J]. 基础医学与临床, 2020, 40(4): 547-551.

HE Zhen-hua, SHEN Fu-hui, ZENG Fan-gang, LIU Qian-lin, YUAN Jing-min. Research progress of nucleostemin signaling pathway in tumorigenesis and development[J]. Basic & Clinical Medicine, 2020, 40(4): 547-551.

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