细胞焦亡与心血管疾病研究进展

基础医学与临床 ›› 2020, Vol. 40 ›› Issue (12): 1711-1715.

细胞焦亡与心血管疾病研究进展

朱坤¹, 戴日蕾², 朱文婷¹, 李贞燕¹, 曹春梅^1,2,3*

1.首都儿科研究所生理研究室,北京 100020;
2.北京市临床医学研究所心血管实验室,北京 100050;
3.首都医科大学附属北京友谊医院心内科, 北京 100050

收稿日期:2020-09-14 修回日期:2020-10-23 出版日期:2020-12-05 发布日期:2020-11-30
通讯作者: ^* caochunmei@pku.edu.cn
基金资助:
国家自然科学基金(81870231)

Progress in research on pyroptosis and cardiovascular diseases

ZHU Kun¹, DAI Ri-lei², ZHU Wen-ting¹, LI Zhen-yan¹, CAO Chun-mei^1,2,3*

1. Department of Physiology, Capital Institute of Pediatrics, Beijing 100020;
2. Laboratory of Cardiovascular Science, Beijing Clinical Research Institute, Beijing 100050;
3. Department of Cardiology, Beijing Friendship Hospital, Capital Medical University, Beijing 100050, China

Received:2020-09-14 Revised:2020-10-23 Online:2020-12-05 Published:2020-11-30
Contact: ^* caochunmei@pku.edu.cn

摘要/Abstract

摘要： 细胞焦亡是由gasdermin蛋白介导的程序性细胞死亡,包括依赖caspase-1的经典途径和依赖caspase-4、-5、-11的非经典途径,伴随着大量炎性因子的释放。动脉粥样硬化、心肌缺血以及心力衰竭等多种心血管疾病均与炎性反应密切相关。而细胞焦亡作为一种高度促炎性的细胞死亡也广泛参与了以上疾病的发生发展,在心血管相关疾病中发挥重要作用。

关键词: 细胞焦亡, 炎性小体, 心血管疾病

Abstract: Pyroptosis is a kind of programmed cell death mediated by the gasdermin protein, including the classical pathway that depends on caspase-1 and the non-classical pathway that depends on caspase-4, -5, and 11, accompanied by the release of a large number of inflammatory factors. Atherosclerosis, myocardial ischemia, heart failure and other cardiovascular diseases are closely related to inflammatory response. Pyroptosis, as a highly pro-inflammatory cell death, is also widely involved in the occurrence and development of the cardiovascular diseases, and plays an important role in these diseases.

Key words: pyroptosis, inflammasomes, cardiovascular diseases

中图分类号:

R331.3

朱坤, 戴日蕾, 朱文婷, 李贞燕, 曹春梅. 细胞焦亡与心血管疾病研究进展[J]. 基础医学与临床, 2020, 40(12): 1711-1715.

ZHU Kun, DAI Ri-lei, ZHU Wen-ting, LI Zhen-yan, CAO Chun-mei. Progress in research on pyroptosis and cardiovascular diseases[J]. Basic & Clinical Medicine, 2020, 40(12): 1711-1715.

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