含有白细胞的富血小板纤维蛋白的生物学特性及临床应用

基础医学与临床 ›› 2020, Vol. 40 ›› Issue (12): 1706-1710.

含有白细胞的富血小板纤维蛋白的生物学特性及临床应用

孙慧颖¹, 朱崇元², 冯国栋¹, 高志强^1*

1.中国医学科学院北京协和医学院北京协和医院耳鼻咽喉科, 北京 100730;
2.潍坊医学院耳鼻咽喉科, 山东潍坊 261053

收稿日期:2019-09-27 修回日期:2020-01-03 出版日期:2020-12-05 发布日期:2020-11-30
通讯作者: ^* talllee@sina.com
基金资助:
国家重点研发计划干细胞及转化研究专项(2016YFA0101002)

Biological characteristics and clinical application of leucocyte-and platelet-rich fibrin

SUN Hui-ying¹, ZHU Chong-yuan², FENG Guo-dong¹, GAO Zhi-qiang^1*

1. Department of Otorhinolaryngology,Peking Union Medical College Hospital,CAMS & PUMC,Beijing 100730;
2. Department of Otorhinolaryngology, Weifang Medical University, Weifang 261053, China

Received:2019-09-27 Revised:2020-01-03 Online:2020-12-05 Published:2020-11-30
Contact: ^* talllee@sina.com

摘要/Abstract

摘要： 自体血液制品作为特殊的生物制剂在临床应用中日益得到重视。含有白细胞的富血小板纤维蛋白(L-PRF)是最具标志性的第二代富血小板血液制品,其较第一代富血小板血浆(PRP)具有更规则、稳定的纤维蛋白网,并含有更加丰富的生长因子及细胞因子,生物学效应更强;且L-PRF制备更简单、安全性更高。目前L-PRF已广泛应用于口腔科、骨科、整形外科的组织修复及重建工作中,且有望在耳外科手术中作为自体材料修复软组织及骨质缺损。

关键词: 含有白细胞的富血小板纤维蛋白, 富血小板血浆, 组织修复重建, 外耳道重建

Abstract: Autologous blood-derived products get more attention as a special kind of biological products. Leucocyte-and platelet-rich fibrin (L-PRF) is the most classic second-generation platelet concentrates of autologous blood-derived products. It has more advantages than the first-generation products like platelet-rich plasma (PRP), because of the more stable fibrin network, higher concentration of cytokines and growth factors, and higher biological effects. Besides, L-PRF is easier to obtain and safer for the body. Now it has been widely used in department of stomatology, orthopedics and plastic surgery. L-PRF has the potential to serve as an ideal material for recovery and construction of soft tissues and bony defect in oncology surgery.

Key words: L-PRF, PRP, tissue repair and reconstruction, reconstruction of external ear canal

中图分类号:

Q813

孙慧颖, 朱崇元, 冯国栋, 高志强. 含有白细胞的富血小板纤维蛋白的生物学特性及临床应用[J]. 基础医学与临床, 2020, 40(12): 1706-1710.

SUN Hui-ying, ZHU Chong-yuan, FENG Guo-dong, GAO Zhi-qiang. Biological characteristics and clinical application of leucocyte-and platelet-rich fibrin[J]. Basic & Clinical Medicine, 2020, 40(12): 1706-1710.

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