基础医学与临床 ›› 2019, Vol. 39 ›› Issue (9): 1366-1370.

• 短篇综述 • 上一篇    下一篇

表观遗传调控异常在慢性肾脏病Klotho减少中的作用

李莎莎,刘其锋,何敖林   

  1. 昆山市第一人民医院
  • 收稿日期:2018-11-08 修回日期:2019-02-07 出版日期:2019-09-05 发布日期:2019-09-06
  • 通讯作者: 何敖林 E-mail:olin@vip.163.com
  • 基金资助:
    苏州市“科教兴卫”青年科技项目

Role of epigenetic regulation abnormality in Klotho deficiency of chronic kidney disease

  • Received:2018-11-08 Revised:2019-02-07 Online:2019-09-05 Published:2019-09-06

摘要: 慢性肾脏病(CKD)是肾保护因子Klotho蛋白的持续缺乏状态,而klotho基因的表观遗传调控异常是引起Klotho减少的一个重要原因。明确klotho基因的表观调控异常与Klotho减少的关系,对于将来靶向调控Klotho的表达,发挥肾脏保护作用具有重要意义。

关键词: 表观遗传调控, Klotho, 慢性肾脏病

Abstract: Chronic kidney disease (CKD) is the persistent state of reno-protective Klotho protein deficiency. The abnormality of klotho epigenetic regulation is regarded as a major cause which reduces the expression of Klotho. Thus, it is important to elucidate the association between the abnormality of klotho epigenetic regulation and Klotho deficiency for reno-protection by targeted regulation of Klotho expression.

Key words: Epigenetic regulation, Klotho, chronic kidney disease