基础医学与临床 ›› 2019, Vol. 39 ›› Issue (9): 1366-1370.
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李莎莎,刘其锋,何敖林
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摘要： 慢性肾脏病（CKD）是肾保护因子Klotho蛋白的持续缺乏状态，而klotho基因的表观遗传调控异常是引起Klotho减少的一个重要原因。明确klotho基因的表观调控异常与Klotho减少的关系，对于将来靶向调控Klotho的表达，发挥肾脏保护作用具有重要意义。
关键词: 表观遗传调控, Klotho, 慢性肾脏病
Abstract: Chronic kidney disease (CKD) is the persistent state of reno-protective Klotho protein deficiency. The abnormality of klotho epigenetic regulation is regarded as a major cause which reduces the expression of Klotho. Thus, it is important to elucidate the association between the abnormality of klotho epigenetic regulation and Klotho deficiency for reno-protection by targeted regulation of Klotho expression.
Key words: Epigenetic regulation, Klotho, chronic kidney disease
李莎莎 刘其锋 何敖林. 表观遗传调控异常在慢性肾脏病Klotho减少中的作用[J]. 基础医学与临床, 2019, 39(9): 1366-1370.
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链接本文: https://journal11.magtechjournal.com/Jwk_jcyxylc/CN/
https://journal11.magtechjournal.com/Jwk_jcyxylc/CN/Y2019/V39/I9/1366
