›› 2019, Vol. 39 ›› Issue (11): 1644-1648.

• 短篇综述 • 上一篇    下一篇



  1. 中国医学科学院 北京协和医学院 北京协和医院
  • 收稿日期:2019-07-08 修回日期:2019-09-17 出版日期:2019-11-05 发布日期:2019-11-05
  • 通讯作者: 于健春 E-mail:yu-jch@163.com
  • 基金资助:

Research progress of tumor-associated macrophages in development and treatment of gastric cancer

Ying-Jing ZHANG1,Jian-chun -YU   

  • Received:2019-07-08 Revised:2019-09-17 Online:2019-11-05 Published:2019-11-05
  • Contact: Jian-chun -YU E-mail:yu-jch@163.com

摘要: 胃癌是全球发病率和病死率较高的恶性肿瘤,随着治疗手段的进步与发展,患者的生存期得到了明显的改善。肿瘤相关巨噬细胞(TAMs)是肿瘤微环境的重要组成部分,参与调控胃癌细胞增殖、侵袭、免疫逃逸和化疗耐药等各个方面,在胃癌预后评估和靶向治疗中也已显现出极大的潜力。

关键词: 肿瘤相关巨噬细胞, 胃癌, 免疫逃逸, 预后标志物, 治疗靶点

Abstract: Gastric cancer is one of the malignant tumors with highest morbidity and mortality in the world. With the development of treatments, the survival of patients has been significantly improved. Tumor-associated macrophages (TAMs) are the important part of the tumor microenvironment, which involved in the regulation of gastric cancer cell growth, invasion, immune escape and chemotherapy resistance. In addition, TAMs have shown great potential in evaluating prognosis and targeted therapy for gastric cancer.

Key words: tumor-associated macrophages, gastric cancer, immune escape, prognostic marker, therapeutic target