基础医学与临床 ›› 2018, Vol. 38 ›› Issue (4): 568-572.
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宋华琛,唐晓楠,张海婧,王文杰,吴练秋
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摘要： 结肠炎相关结肠癌（CAC）的发生和发展与溃疡性结肠炎（UC）密切相关。CAC发生、发展和恶性变相关的主要发病机制包括核转录因子（NF-κB）通路、信号转导子和转录激活子（STAT）与相关蛋白通路、肠道菌群失衡、免疫微环境和Toll样受体（TLRs）相关通路等方面内容。
关键词: 溃疡性结肠炎, 结肠炎相关结肠癌, 发病机制
Abstract: The ulcerative colitis is closely related to the development of colitis associated cancer. The main mechanisms related to the occurrence, development and malignant transformation of CAC includes NF-κB pathway, signal transducers and activator of transcription (STAT) and related protein pathways, intestinal microflora imbalance, the immune microenvironment and Toll-like receptor (TLR) -related pathway and so on.
Key words: ulcerative colitis, colitis-associated colon cancer, pathogenesis mechanism
宋华琛 唐晓楠 张海婧 王文杰 吴练秋. 结肠炎相关结肠癌机制研究进展[J]. 基础医学与临床, 2018, 38(4): 568-572.
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