基础医学与临床 ›› 2017, Vol. 37 ›› Issue (9): 1326-1330.
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解修峰,史志周
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摘要: 肿瘤及其微环境来源的外泌体miRNAs可以促进肿瘤细胞增殖和侵袭运动;通过介导肿瘤细胞与免疫细胞、转移靶器官间的信息交流促进肿瘤细胞定向转移;诱发肿瘤细胞对顺铂和吉西他滨等的耐药;同时针对肿瘤患者血清和唾液中外泌体miRNAs的检测显示出应用于肿瘤诊断和预后判断的潜在重要价值。
关键词: 肿瘤, 微环境, 外泌体, miRNAs, 致癌机制
Abstract: Exosomal miRNAs, derived from tumor cells or their microenvironment, could promote the proliferation, migration and invasion of tumor cells; and enhance tumor metastasis via regulating information exchange between tumor cells and immune cells or metastatic target organs; and induce tumor resistance to cisplatin and gemcitabine; meanwhile, detecting the exosomal miRNAs in the serum and saliva of cancer patients suggested the potential of application in cancer diagnosis and prognosis assessment.
Key words: tumor, microenvironment, exosome, miRNAs, tumorigenic mechanism.
中图分类号:
R363
解修峰 史志周. 肿瘤及其微环境源性外泌体miRNAs在致癌机制、肿瘤诊断和治疗中的研究进展[J]. 基础医学与临床, 2017, 37(9): 1326-1330.
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http://journal11.magtechjournal.com/Jwk_jcyxylc/CN/Y2017/V37/I9/1326