基础医学与临床 ›› 2017, Vol. 37 ›› Issue (9): 1331-1335.

• 短篇综述 • 上一篇    下一篇

人诱导性多潜能干细胞建立心肌细胞疾病模型的研究进展

崔宁1,李蕾1,崔鸣1,兰峰2   

  1. 1. 北京大学第三医院
    2. 首都医科大学附属北京安贞医院
  • 收稿日期:2017-02-04 修回日期:2017-06-24 出版日期:2017-09-05 发布日期:2017-08-28
  • 通讯作者: 崔鸣 E-mail:mingcui@bjmu.edu.cn

Research progress of establishing cardiomyocyte disease models by human induced pluripotent stem cells

  • Received:2017-02-04 Revised:2017-06-24 Online:2017-09-05 Published:2017-08-28

摘要: 诱导性多潜能干细胞是干细胞研究领域里程碑式的发现,近10年发展迅速。通过体细胞获得诱导性多潜能干细胞,再进一步分化成心肌细胞,可建立不同的心肌细胞疾病模型,并用于疾病的机制研究、药物筛选、基因治疗等。本文对已成功构建的人诱导多潜能干细胞来源的心肌细胞疾病模型进行了介绍,并指出了其面临的问题及展望。

关键词: 诱导性多潜能干细胞, 心肌细胞疾病模型, 研究进展

Abstract: Induced pluripotent stem cell is a landmark in the stem cell study field, which has developed rapidly in the past 10 years. By obtaining induced pluripotent stem cells from somatic cell, and then differentiating into cardiomyocyte, various cardiomyocyte disease models could be established,which can be used for research of disease mechanisms, drug screening and gene therapy. This review introduces the successfully established cardiomyocyte disease models from human induced pluripotent stem cells, and points out the problems and prospects.

Key words: induced pluripotent stem cell, cardiomyocyte disease model, research progress