基础医学与临床 ›› 2016, Vol. 36 ›› Issue (2): 272-276.
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张文静1,邓文彬2,秦鑫1
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摘要： 上皮间质转化(EMT)是肿瘤侵袭和转移的关键环节。转录因子SNAIL、TWIST和ZEB在EMT中作用研究较多。它们转录调控EMT相关分子标记物的表达。同时，它们受表观遗传学、转录水平和转录后水平复杂而精准的调控。阐明转录因子调控EMT在肿瘤侵袭和转移中的分子生物学机制，将为肿瘤侵袭和转移的靶向治疗和药物研发提供新思路。
关键词: 转录因子, 上皮间质化, 肿瘤, 侵袭, 转移
Abstract: Epithelial-mesenchymal transition (EMT) is regarded as a key step in cancer invasion and metastasis. Transcriptional factors (TFs) are the primary clues in initiating EMT, such as SNAIL, TWIST and ZEB. TFs modulate transcription of EMT-associated genes. Meanwhile, they also experienced epigenetic reprogramming and transcriptional and post-transcriptional regulation. Elucidation the molecular mechanisms of TF-driven EMT in cancer invasion and metastasis would provide new insights in target therapy and drug design.
Key words: Transcriptional factor, Epithelial-mesenchymal transition, Cancer, Invasion, Metastasis
中图分类号:
R73-37
张文静 邓文彬 秦鑫. 转录因子调控EMT参与肿瘤侵袭和转移[J]. 基础医学与临床, 2016, 36(2): 272-276.
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