基础医学与临床 ›› 2016, Vol. 36 ›› Issue (2): 258-261.
• 短篇综述 • 上一篇 下一篇
高增法1,吴永娜2,3,杜海云4,李汛2
收稿日期:
修回日期:
出版日期:
发布日期:
通讯作者:
基金资助:
Received:
Revised:
Online:
Published:
Contact:
摘要: 神经菌毛蛋白1(NRP1)是NRP家族的重要一员,其作为多种细胞外基质配体的共受体在神经发育、血管生成、肿瘤侵袭转移和免疫等方面发挥重要作用。NRP1可通过多种机制促进肿瘤的血管生成和肿瘤增殖转移,同时在免疫系统中可调节初级免疫反应并且是抗肿瘤免疫的关键因素。NRP1的进一步研究将为神经系统、 血管系统及肿瘤的治疗提供新的方向和机遇。
关键词: 神经菌毛蛋白1(NRP1), 血管生成, 恶性肿瘤, 免疫
Abstract: Neuropilin-1(NRP1) is an important member of the NRP-family, which plays an important role in neural development, angiogenesis, tumor metastasis and immunity as NRP1 in various fields. NRP1 can promote tumor angiogenesis, proliferation and metastasis through a variety of mechanisms, while in the immune system it can regulate the primary immune response and which is a key factor in anti-tumor immunity. Further research of NRP1 will provide new directions and opportunities for the nervous system, vascular system and tumor treatment.
Key words: neuropilin-1(NRP1), angiogenesis, malignancies, immunity
中图分类号:
R730.5
高增法 吴永娜 杜海云 李汛. 神经菌毛蛋白1的研究进展[J]. 基础医学与临床, 2016, 36(2): 258-261.
0 / / 推荐
导出引用管理器 EndNote|Reference Manager|ProCite|BibTeX|RefWorks
链接本文: http://journal11.magtechjournal.com/Jwk_jcyxylc/CN/
http://journal11.magtechjournal.com/Jwk_jcyxylc/CN/Y2016/V36/I2/258