基础医学与临床 ›› 2016, Vol. 36 ›› Issue (12): 1743-1746.
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熊洋洋1,李源杰1,曾学军2
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摘要: 痛风石是慢性期痛风的特征性表现,药物治疗起效缓慢,长期存在影响患者的心身健康。中性粒细胞胞外网状陷阱(NETs)可能参与了痛风石的形成,并且可通过降低炎症因子和趋化因子水平从而限制痛风急性期炎性反应。早期诊断水平的提高、新药的出现和手术方法的改进有助于预防痛风石的进一步损害。
关键词: 痛风石, 中性粒细胞胞外网状陷阱, 诊断, 治疗
Abstract: The tophus is the characteristic feature of advanced gout,which usually causes functional and psychological deficiency,and it always takes a long time for the drug therapy to take effect. Neutrophil extracellular traps(NETs) may lead to the formation of tophus and can limit acute inflammation by degrading cytokines and chemokines.Recently,the improvement of early diagnosis,new drugs and surgical methods can contribute to the prevent of the further destruction of tophaceous gout.
Key words: tophaceous gout, neutrophil extracellular traps, diagnosis, therapy
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R589.7
熊洋洋 李源杰 曾学军. 痛风石的基础研究与临床诊治进展[J]. 基础医学与临床, 2016, 36(12): 1743-1746.
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