基础医学与临床 ›› 2016, Vol. 36 ›› Issue (11): 1596-1602.
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李甜甜,张江宇,李荔
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摘要： 多囊卵巢综合征（PCOS）是一种生殖功能障碍合并代谢障碍的内分泌疾病，其病因及发病机制尚未明确。磷酯酰肌醇-3激酶/蛋白激酶B(PI3K/Akt)信号通路中的信号分子及蛋白的改变与PCOS患者胰岛素抵抗的发生、脂肪细胞的分化、细胞增殖及治疗预后有关。
关键词: 多囊卵巢综合征, PI3K-Akt, 信号传导, 胰岛素抵抗, 发病机制
Abstract: Polycystic ovary syndrome (PCOS) is a common endocrine disease, with reproductive functional disturbance and metabolic disorders. However, its etiology and pathogenesis are not clear yet. Inside the cell, phosphatidylinositol 3-kinase/Protein Kinase B (PI3K-Akt) is one of the important signal pathway, and the change of PI3K-Akt signal pathway is related to processes of PCOS, such as insulin resistance, adipocyte differentiation, cell proliferation, treatment and prognosis.
Key words: polycystic ovary syndrome, PI3K-Akt, signal transduction, insulin resistance, pathogenesis
中图分类号:
R713
李甜甜 张江宇 李荔. PI3K/Akt在多囊卵巢综合征发病机制中作用的研究进展[J]. 基础医学与临床, 2016, 36(11): 1596-1602.
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