基础医学与临床 ›› 2015, Vol. 35 ›› Issue (4): 531-535.

• 短篇综述 • 上一篇    下一篇

miR-124在肿瘤研究中的进展

钟阿红1,许希中2,余进进1,吴亦波3   

  1. 1. 苏州大学附属第四医院
    2. 江南大学附属医院无锡市第四人民医院
    3. 江南大学附属医院/无锡市第四人民医院
  • 收稿日期:2014-09-22 修回日期:2014-11-27 出版日期:2015-04-05 发布日期:2015-04-08
  • 通讯作者: 余进进 E-mail:yujjwx@126.com
  • 基金资助:
    江苏省科技计划项目;无锡市科技计划项目

Advancements of miR-124 on neoplasm

  • Received:2014-09-22 Revised:2014-11-27 Online:2015-04-05 Published:2015-04-08
  • Supported by:
    the project of youth fund of Jiangsu province; the project of Wuxi science and technology bureau

摘要: MicroRNA(miRNA)是一类在生物体内广泛表达的非编码小分子RNA,不仅参与调节生物体的生长发育,还与包括肿瘤在内的多种疾病的发生发展密切相关。miR-124就是其中之一,它是一个高度保守的抑癌miRNA。研究发现miR-124在多种肿瘤中均表达下调,已被证实在该类肿瘤的发生、发展以及预后中起着重要作用。

关键词: microRNA (miRNA), miR-124, 功能, 肿瘤

Abstract: MicroRNA(miRNA)are a class of short non-coding RNA molecules,which diversely regulate gene expression in organisms. MiRNAs have been found to perform a pivotal role not only in various biologic processes, but also in abnormal state including the occurrence and development of neoplasm. MiR-124, which is highly conserved, is down-expressed in various human neoplasm and is closely related to the occurrence, development and prognosis of neoplasm, as the key anti-oncogenic component.

Key words: microRNA (miRNA), miR-124, function, neoplasm

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