维生素D3与非酒精性脂肪性肝炎的研究进展

基础医学与临床 ›› 2015, Vol. 35 ›› Issue (12): 1705-1708.

维生素D3与非酒精性脂肪性肝炎的研究进展

韩红梅,朴熙绪

延边大学附属医院

收稿日期:2015-04-23 修回日期:2015-07-01 出版日期:2015-12-05 发布日期:2015-12-04
通讯作者: 朴熙绪 E-mail:xixupiao@aliyun.com
基金资助:
延边大学科技发展计划项目

Research progress on vitamin D3 and non-alcoholic steatohepatitis

Received:2015-04-23 Revised:2015-07-01 Online:2015-12-05 Published:2015-12-04
Supported by:
the Yanbian University Science

摘要/Abstract

摘要： 非酒精性脂肪性肝炎（NASH）是非酒精性脂肪性肝病（NAFLD）的最重要形式，可发展为肝硬化和肝癌。在啮齿类动物中发现维生素D3（VD3）具有抗氧化、抗凋亡、抗炎和抗肝纤维化的作用。补充VD3可部分改善NASH的进展。VD3有望成为临床治疗NASH的有效药物。

关键词: 维生素D3, 非酒精性脂肪性肝炎

Abstract: Non-alcoholic steatohepatitis (NASH) is recognized as the most severe form of non-alcoholic fatty liver disease (NAFLD), with likely progression to liver cirrhosis and hepatocellular carcinoma. Vitamin D3 (VD3) has been shown to act as anti-oxidant, anti-apoptotic, anti-inflammatory and anti-fibrotic compound in rodents. VD3 supplementation partly ameliorated the NASH progression. VD3 can be an effective approach for the intervention in clinical NASH.

Key words: Vitamin D3, non-alcoholic steatohepatitis

中图分类号:

R856.5

韩红梅朴熙绪. 维生素D3与非酒精性脂肪性肝炎的研究进展[J]. 基础医学与临床, 2015, 35(12): 1705-1708.