基础医学与临床 ›› 2015, Vol. 35 ›› Issue (10): 1414-1418.
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尹博炜1,张谢2,李宏2
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摘要： 抑癌基因PTEN的缺失和突变常常和肿瘤的发生发展密切相关。而除了基因的缺失和突变，PTEN也受到许多非基因机制的调控，如转录调控、表观沉默、非编码RNA的转录后调控、翻译后修饰。
关键词: PTEN, 肿瘤抑制因子, PI3K/AKT信号通路, 非基因型调控, 肿瘤
Abstract: Mutations and deletions of the tumour suppressor PTEN are frequently involved in the development of cancer. However, PTEN is also tightly controlled by various non-genomic mechanisms，such as the epigenetic silencing of PTEN, post-transcriptional regulation by non-coding RNAs and post-translational modification.
Key words: PTEN, Tumour suppressor, PI3K–Akt/PKB pathway, non-genetic regulation, Cancer
中图分类号:
R735.7
尹博炜 张谢 李宏. 抑癌基因PTEN非基因调控的研究进展[J]. 基础医学与临床, 2015, 35(10): 1414-1418.
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http://journal11.magtechjournal.com/Jwk_jcyxylc/CN/Y2015/V35/I10/1414
