长链非编码RNA ANRIL的研究进展

基础医学与临床 ›› 2015, Vol. 35 ›› Issue (10): 1419-1423.

长链非编码RNA ANRIL的研究进展

江澈¹,王伟民²

1. 广州军区广州总医院
2. 广州军区广州总医院脑病中心

收稿日期:2015-03-17 修回日期:2015-05-28 出版日期:2015-10-05 发布日期:2015-09-30
通讯作者: 江澈 E-mail:jiang.c@vip.126.com

Research progress in the long non-coding RNA ANRIL

Received:2015-03-17 Revised:2015-05-28 Online:2015-10-05 Published:2015-09-30
Contact: Che Jiang E-mail:jiang.c@vip.126.com

摘要/Abstract

摘要： 长链非编码RNAs是基因表达的重要调控子。Chr9p21.3位点的长链非编码RNA ANRIL广泛参与肿瘤、冠心病及2型糖尿病等多种疾病的发生和发展。ANRIL的多种同工型具有组织特异性。ANRIL主要以多梳蛋白通路发挥作用，同时也存在其他下游靶点。每种同工型的作用机制和下游的多种通路是目前研究的热点。

关键词: 长链非编码RNA，ANRIL，CDKN2BAS

Abstract: Long non-coding RNAs are important regulators of gene expression. ANRIL which was coded on the Chr9p21.3 loci participates in the pathogenesis of tumor, coronary artery disease, type 2 diabetes mellitus and other diseases. Multiple ANRIL isoforms are tissue-specific. ANRIL mainly functions through Polycomb proteins, while there are also other downstream targets. The mechanism of each isoform and the downstream pathways are hotspots currently.

Key words: Long non-coding RNA, ANRIL, CDKN2BAS

江澈王伟民. 长链非编码RNA ANRIL的研究进展[J]. 基础医学与临床, 2015, 35(10): 1419-1423.