基础医学与临床 ›› 2014, Vol. 34 ›› Issue (7): 1010-1013.
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陈刚
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摘要： Sirtuins是第III类组蛋白去乙酰化酶，主要成员SIRT1、SIRT6与慢性阻塞性肺疾病（COPD）发病机制有密切关系。SIRT1、SIRT6在COPD患者肺部中表达下调，并通过多种机制调节炎性反应、肺部自噬与衰老。Sirtuins可能是COPD发生过程中的一个调控分子家族。
关键词: 慢性阻塞性肺病, Sirtuins, SIRT1, SIRT6
Abstract: Sirtuins are class III histone deacetylase. SIRT1 and SIRT6 are the major members of Sirtuins participated in the development of chronic obstructive pulmonary disease(COPD). The expression of SIRT1 and SIRT6 were down-regulated in the lungs of patients with COPD, and they regulate inflammatory reaction, lung autophagy and senescence through multiple mechanisms. Sirtuins may be one of main regulatory molecules family in the progression of COPD.
Key words: COPD, Sirtuins, SIRT1, SIRT6
陈刚. 慢性阻塞性肺病Sirtuins的研究进展[J]. 基础医学与临床, 2014, 34(7): 1010-1013.
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http://journal11.magtechjournal.com/Jwk_jcyxylc/CN/Y2014/V34/I7/1010
