基础医学与临床 ›› 2014, Vol. 34 ›› Issue (3): 422-425.

• 短篇综述 • 上一篇    下一篇

结直肠癌肿瘤干细胞标志物的研究进展

陈倩倩1,毋永娟2   

  1. 1. 内蒙古科技大学包头医学院
    2. 包头市肿瘤医院
  • 收稿日期:2013-06-03 修回日期:2013-09-25 出版日期:2014-03-05 发布日期:2014-02-27
  • 通讯作者: 毋永娟 E-mail:yongjuan1052@sina.com
  • 基金资助:
    干细胞标记物CD44、CD24在结直肠癌/腺瘤中的表达及其与致瘤和侵袭能力的相关性研究

Research Progress on Bio Maker of Colorectal Cancer Stem Cell

  • Received:2013-06-03 Revised:2013-09-25 Online:2014-03-05 Published:2014-02-27

摘要: CD44+、CD24+、CD166+、CD29+等参与结直肠癌的发生、侵袭和复发,表达越高预后越差,可作为结直肠癌肿瘤干细胞标志物,与其相关的信号传导通路和蛋白酶通过调节内环境也参与肿瘤的形成。通过研究肿瘤干细胞标志物可以早期诊断结直肠癌,减少肿瘤的复发,寻找治疗靶点,为结直肠癌的诊治提供突破点。

关键词: 关键词:结直肠癌, 肿瘤干细胞(TSCs), 标志物

Abstract: CD44+、CD24+、CD166+ and CD29+ can be as colorectal cancer stem cell markers. They are involved in colorectal cancer incidence、invasion and recurrence, the higher expression of the worse prognosis. At the same time, the associated signal transduction pathways and proteases can adjust internal environment and involve in tumor formation. Based on studies of colorectal cancer stem cell surface markers, the early presence of the tumor can be detected, tumor recurrence are reduced, and find targets and breakthrough in diagnosis and treatment of colorectal cancer.

Key words: Key words:colorectal cancer, tumor stem cells(TSCs), maker

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